1nor

<StructureSection load='1nor' size='340' side='right'caption='[[1nor]], [[NMR_Ensembles_of_Models | 19 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1nor]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Central_asian_cobra Central asian cobra]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NOR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NOR FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nor FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nor OCA], [https://pdbe.org/1nor PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nor RCSB], [https://www.ebi.ac.uk/pdbsum/1nor PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nor ProSAT]</span></td></tr>

[[https://www.uniprot.org/uniprot/NXS1_NAJOX NXS1_NAJOX]] Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site. Binds to the muscular nicotinic acetylcholine receptor.

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== Publication Abstract from PubMed ==

The spatial structure of neurotoxin II from the venom of the central Asian cobra Naja naja oxiana was determined by two-dimensional 1H-NMR techniques and computational analysis. Nearly complete proton resonance assignments for 61 amino acid residues have been made using two-dimensional (2D) homonuclear total correlated spectroscopy, 2D homonuclear double-quantum-filtered correlated spectroscopy and 2D homonuclear NOE spectroscopy (NOESY) experiments. The cross-peak volumes in NOESY spectra spin-spin coupling constants of vicinal protons NH-C alpha H and C alpha H-C beta H and the observation of slow deuterium exchange of amide protons were used to define local structure and a set of constraints for distance geometry program DIANA. The average root-mean-square deviations are 53 pm for backbone heavy atoms and 118 pm for all heavy atoms of 19 final neurotoxin II conformations. The spatial structure is characterized by a short double-stranded (residues 1-5 and 13-17) and a triple-stranded (residues 22-30, 33-41 and 50-54) antiparallel beta-sheets.

Two-dimensional 1H-NMR study of the spatial structure of neurotoxin II from Naja naja oxiana.,Golovanov AP, Lomize AL, Arseniev AS, Utkin YN, Tsetlin VI Eur J Biochem. 1993 May 1;213(3):1213-23. PMID:8504813<ref>PMID:8504813</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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== References ==

<references/>

[[Category: Central asian cobra]]

[[Category: Arseniev, A S]]

[[Category: Golovanov, A P]]

[[Category: Lomize, A L]]

[[Category: Tsetlin, V I]]

[[Category: Utkin, Y N]]

[[Category: Neurotoxin]]