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1nzn
From Proteopedia
(Difference between revisions)
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<StructureSection load='1nzn' size='340' side='right'caption='[[1nzn]], [[Resolution|resolution]] 2.00Å' scene=''> | <StructureSection load='1nzn' size='340' side='right'caption='[[1nzn]], [[Resolution|resolution]] 2.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1nzn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1nzn]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NZN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1NZN FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nzn OCA], [https://pdbe.org/1nzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nzn RCSB], [https://www.ebi.ac.uk/pdbsum/1nzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nzn ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1nzn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nzn OCA], [https://pdbe.org/1nzn PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1nzn RCSB], [https://www.ebi.ac.uk/pdbsum/1nzn PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1nzn ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/FIS1_HUMAN FIS1_HUMAN] Promotes the fragmentation of the mitochondrial network and its perinuclear clustering. Can induce cytochrome c release from the mitochondrion to the cytosol, ultimately leading to apoptosis. Also mediates peroxisomal fission.<ref>PMID:12783892</ref> <ref>PMID:12861026</ref> <ref>PMID:14996942</ref> <ref>PMID:16118244</ref> <ref>PMID:16107562</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Dohm | + | [[Category: Dohm JA]] |
| - | [[Category: Gittis | + | [[Category: Gittis AG]] |
| - | [[Category: Hill | + | [[Category: Hill RB]] |
| - | + | ||
| - | + | ||
Current revision
Cytosolic domain of the human mitchondrial fission protein Fis1 adopts a TPR fold
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