User:Mandy Bechman/Sandbox 1
From Proteopedia
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The idea of incretin began in 1902 after the discovery of secretin by Bayliss and Starling. Inspired by their discovery, Moore et al. hypothesized that there must be some kind of gut hormone that regulates the endocrine pancreas. His experiments showed that gut extracts in patients with diabetes have reduced amounts of sugars in their urine as a result of endocrine stimulation. In 1929, a French scientist named La Barre was able to purify incretin from gut extracts. The name incretin comes from INtestine seCRETion INsulin.<ref name="Seino"/> | The idea of incretin began in 1902 after the discovery of secretin by Bayliss and Starling. Inspired by their discovery, Moore et al. hypothesized that there must be some kind of gut hormone that regulates the endocrine pancreas. His experiments showed that gut extracts in patients with diabetes have reduced amounts of sugars in their urine as a result of endocrine stimulation. In 1929, a French scientist named La Barre was able to purify incretin from gut extracts. The name incretin comes from INtestine seCRETion INsulin.<ref name="Seino"/> | ||
==Structure Overview== | ==Structure Overview== | ||
| - | GIP is a G-coupled receptor. It is composed of the alpha, beta, and gamma <scene name='10/1038867/Structure_overview/ | + | GIP is a G-coupled receptor. It is composed of the alpha, beta, and gamma <scene name='10/1038867/Structure_overview/5'>subunits</scene>. |
[https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020673/ Function] | [https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4020673/ Function] | ||
Revision as of 13:29, 11 April 2024
H. sapiens Glucose-dependent Insulinotropic Polypeptide
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References
- ↑ 1.0 1.1 Mayendraraj A, Rosenkilde MM, Gasbjerg LS. GLP-1 and GIP receptor signaling in beta cells interactions and co-stimulation. Peptides. 2022 May;151:170749. PMID:35065096 doi:10.1016/j.peptides.2022.170749
- ↑ 2.0 2.1 Seino Y, Fukushima M, Yabe D. GIP and GLP-1, the two incretin hormones: Similarities and differences. J Diabetes Investig. 2010 Apr 22;1(1-2):8-23. PMID:24843404 doi:10.1111/j.2040-1124.2010.00022.x
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
