From Proteopedia

Revision as of 14:07, 11 April 2024

GIP and GIP-R

spinqualitylabelsall models GIP with GIP receptor Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image This is a default text for your page Chloe Tucker/Sandbox 1. Click above on edit this page to modify. Be careful with the < and > signs. You may include any references to papers as in: the use of JSmol in Proteopedia [1] or to the article describing Jmol [2] to the rescue. Contents 1 Introduction 2 Function 3 Disease 4 Relevance 5 Structural highlights 5.1 Binding/Active Site of GIPR with GIP 5.2 Binding/Active Site of GIPR with Tirzepatide Introduction Diabetes Function [3]. Disease Relevance Structural highlights This is a sample scene created with SAT to of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. Binding/Active Site of GIPR with GIP Figure 1. Residue Interactions with GIP Binding/Active Site of GIPR with Tirzepatide Figure 2. Residue Interactions with Tirzepatide The is the same as GIP with the N-term binding to the extracellular membrane. The are mostly the same just in a different conformation that is allowing for more hydrogen bonding.

References

1. ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
2. ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
3. ↑ Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2116506119. PMID:35333651 doi:10.1073/pnas.2116506119

Student Contributors

• Chloe Tucker
• Mandy Bechman