User:Chloe Tucker/Sandbox 1

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[[Image:GIP_last_pic.png|350 px|right|thumb|Figure 1. Residue Interactions with GIP]]
[[Image:GIP_last_pic.png|350 px|right|thumb|Figure 1. Residue Interactions with GIP]]
The <scene name='10/1038815/Overview/3'>active site</scene> of GIP with the GIP receptor is where the N-term of GIP binds with the extracellular membrane of the GIP receptor.
The <scene name='10/1038815/Overview/3'>active site</scene> of GIP with the GIP receptor is where the N-term of GIP binds with the extracellular membrane of the GIP receptor.
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The <scene name='10/1038815/GIP Binding Site/1'>residues</scene> within the active site are forming hydrogen bonds with each other and activating the G-protein to start signalling.
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The <scene name='10/1038815/Active_site/1'>residues</scene> within the active site are forming hydrogen bonds with each other and activating the G-protein to start signalling.
=== Binding/Active Site of GIPR with Tirzepatide ===
=== Binding/Active Site of GIPR with Tirzepatide ===
[[Image:TZ_last_pic.png|350 px|right|thumb|Figure 2. Residue Interactions with Tirzepatide]]
[[Image:TZ_last_pic.png|350 px|right|thumb|Figure 2. Residue Interactions with Tirzepatide]]

Revision as of 14:18, 11 April 2024

GIP and GIP-R

GIP with GIP receptor

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References

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2116506119. PMID:35333651 doi:10.1073/pnas.2116506119

Student Contributors

  • Chloe Tucker
  • Mandy Bechman

Proteopedia Page Contributors and Editors (what is this?)

Chloe Tucker

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