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User:Sam Magnabosco/Sandbox1

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[[Image:DPPIV_Proteopedia_1.png|300px|Right|thumb|Figure 1. Catalytic triad of DPPIV with Vildagliptin Bound to active site (Catalytic water is shown in Red).]] Vildagliptin Inhibits DPPIV through a covalent bond to the Ser 608 of the catalytic triad.<ref name=”Berger”>PMID:30815539</ref>
[[Image:DPPIV_Proteopedia_1.png|300px|Right|thumb|Figure 1. Catalytic triad of DPPIV with Vildagliptin Bound to active site (Catalytic water is shown in Red).]] Vildagliptin Inhibits DPPIV through a covalent bond to the Ser 608 of the catalytic triad.<ref name=”Berger”>PMID:30815539</ref>
== Disease ==
== Disease ==
-
<scene name='10/1037493/Beta_propeller/1'>TextToBeDisplayed</scene>
+
 
== Relevance ==
== Relevance ==
== Structural highlights ==
== Structural highlights ==
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<scene name='10/1037491/Dppiv_beta_propellers/3'>DPPIV Beta Propellers</scene>
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Catalytic domain <scene name='10/1037491/Catalytic_domain/3'>catalytic domain</scene>
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<scene name='10/1037491/Vildagliptin_intxns/2'>Vildaglitpin Binding pocket Intxns</scene>
<scene name='10/1037491/Dppiv_with_vildagliptin/4'>DPPIV Movie</scene>
<scene name='10/1037491/Dppiv_with_vildagliptin/4'>DPPIV Movie</scene>
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</StructureSection><scene name='10/1037491/Dppiv_with_vildagliptin_movie/1'>DPPIV intro movie</scene>
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 +
<scene name='10/1037491/Dppiv_with_vildagliptin_movie/1'>DPPIV intro movie</scene>
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</StructureSection>
== References ==
== References ==
<ref name=”Berger”>PMID:30815539</ref>
<ref name=”Berger”>PMID:30815539</ref>

Revision as of 19:06, 11 April 2024

Sam's Killer DPPIV

DPPIV bound to Vildagliptin

Drag the structure with the mouse to rotate

References

[2] [3]

  1. ↑ Berger JP, SinhaRoy R, Pocai A, Kelly TM, Scapin G, Gao YD, Pryor KAD, Wu JK, Eiermann GJ, Xu SS, Zhang X, Tatosian DA, Weber AE, Thornberry NA, Carr RD. A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice. Endocrinol Diabetes Metab. 2017 Nov 24;1(1):e00002. doi: 10.1002/edm2.2., eCollection 2018 Jan. PMID:30815539 doi:http://dx.doi.org/10.1002/edm2.2
  2. ↑ Berger JP, SinhaRoy R, Pocai A, Kelly TM, Scapin G, Gao YD, Pryor KAD, Wu JK, Eiermann GJ, Xu SS, Zhang X, Tatosian DA, Weber AE, Thornberry NA, Carr RD. A comparative study of the binding properties, dipeptidyl peptidase-4 (DPP-4) inhibitory activity and glucose-lowering efficacy of the DPP-4 inhibitors alogliptin, linagliptin, saxagliptin, sitagliptin and vildagliptin in mice. Endocrinol Diabetes Metab. 2017 Nov 24;1(1):e00002. doi: 10.1002/edm2.2., eCollection 2018 Jan. PMID:30815539 doi:http://dx.doi.org/10.1002/edm2.2
  3. ↑ Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677

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Sam Magnabosco

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