1rlw

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[[Image:1rlw.gif|left|200px]]
[[Image:1rlw.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1rlw |SIZE=350|CAPTION= <scene name='initialview01'>1rlw</scene>, resolution 2.4&Aring;
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The line below this paragraph, containing "STRUCTURE_1rlw", creates the "Structure Box" on the page.
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|SITE= <scene name='pdbsite=CA1:Ca+Site+I'>CA1</scene>, <scene name='pdbsite=CA2:Ca+Site+II'>CA2</scene>, <scene name='pdbsite=CR1:Ca-Binding+Region+1'>CR1</scene>, <scene name='pdbsite=CR2:Ca-Binding+Region+2'>CR2</scene> and <scene name='pdbsite=CR3:Ca-Binding+Region+3'>CR3</scene>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CD:CADMIUM+ION'>CD</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Phospholipase_A(2) Phospholipase A(2)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.4 3.1.1.4] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1rlw| PDB=1rlw | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rlw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rlw OCA], [http://www.ebi.ac.uk/pdbsum/1rlw PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rlw RCSB]</span>
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}}
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'''CALCIUM-PHOSPHOLIPID BINDING DOMAIN FROM CYTOSOLIC PHOSPHOLIPASE A2'''
'''CALCIUM-PHOSPHOLIPID BINDING DOMAIN FROM CYTOSOLIC PHOSPHOLIPASE A2'''
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Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2., Perisic O, Fong S, Lynch DE, Bycroft M, Williams RL, J Biol Chem. 1998 Jan 16;273(3):1596-604. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9430701 9430701]
Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2., Perisic O, Fong S, Lynch DE, Bycroft M, Williams RL, J Biol Chem. 1998 Jan 16;273(3):1596-604. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9430701 9430701]
[[Category: Homo sapiens]]
[[Category: Homo sapiens]]
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[[Category: Phospholipase A(2)]]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Perisic, O.]]
[[Category: Perisic, O.]]
[[Category: Williams, R L.]]
[[Category: Williams, R L.]]
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[[Category: c2 domain]]
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[[Category: C2 domain]]
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[[Category: calb domain]]
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[[Category: Calb domain]]
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[[Category: hydrolase]]
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[[Category: Hydrolase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:39:20 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:30:00 2008''
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Revision as of 04:39, 3 May 2008

Image:1rlw.gif

Template:STRUCTURE 1rlw

CALCIUM-PHOSPHOLIPID BINDING DOMAIN FROM CYTOSOLIC PHOSPHOLIPASE A2


Overview

Cytosolic phospholipase A2 (cPLA2) is a calcium-sensitive 85-kDa enzyme that hydrolyzes arachidonic acid-containing membrane phospholipids to initiate the biosynthesis of eicosanoids and platelet-activating factor, potent inflammatory mediators. The calcium-dependent activation of the enzyme is mediated by an N-terminal C2 domain, which is responsible for calcium-dependent translocation of the enzyme to membranes and that enables the intact enzyme to hydrolyze membrane-resident substrates. The 2.4-A x-ray crystal structure of this C2 domain was solved by multiple isomorphous replacement and reveals a beta-sandwich with the same topology as the C2 domain from phosphoinositide-specific phospholipase C delta 1. Two clusters of exposed hydrophobic residues surround two adjacent calcium binding sites. This region, along with an adjoining strip of basic residues, appear to constitute the membrane binding motif. The structure provides a striking insight into the relative importance of hydrophobic and electrostatic components of membrane binding for cPLA2. Although hydrophobic interactions predominate for cPLA2, for other C2 domains such as in "conventional" protein kinase C and synaptotagmins, electrostatic forces prevail.

About this Structure

1RLW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of a calcium-phospholipid binding domain from cytosolic phospholipase A2., Perisic O, Fong S, Lynch DE, Bycroft M, Williams RL, J Biol Chem. 1998 Jan 16;273(3):1596-604. PMID:9430701 Page seeded by OCA on Sat May 3 07:39:20 2008

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