Tau-tubulin kinase

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 12: Line 12:
== Relevance ==
== Relevance ==
-
TTBK1 inhibitors are promising candidates for Alzheimer Disease therapy<ref>PMID:37621404</ref>. TTBK1 phosphorylates TDP-43 and thus its inhibitors can be promising therapeutic targets for treatment of ALS<ref>PMID:34978799</ref>.
+
TTBK1 inhibitors are promising candidates for Alzheimer Disease therapy<ref>PMID:37621404</ref>. TTBK1 phosphorylates TDP-43 and thus its inhibitors can be promising therapeutic targets for treatment of ALS<ref>PMID:34978799</ref>.
== Structural highlights ==
== Structural highlights ==
-
<scene name='10/1042598/Cv/3'>TTBK1 inhibitor interacts with residues which are in the ATP-binding pocket of the protein</scene><ref>PMID:24039150</ref>.
+
<scene name='10/1042598/Cv/4'>TTBK1 inhibitor interacts with residues which are in the ATP-binding pocket of the protein</scene><ref>PMID:24039150</ref>.
==Tau-tubulin kinase 3D structures==
==Tau-tubulin kinase 3D structures==

Revision as of 16:22, 14 April 2024

Human tau-tubulin kinase kinase domain complex with inhibitor, glycerol, sulfate and dimethyl sulfoxide (PDB code 4btm)

Drag the structure with the mouse to rotate

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Tau-tubulin_kinase"
Personal tools