Melanoma-associated antigen

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== Relevance ==
== Relevance ==
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The expression of MAGE-A1 can be a marker for the prediction of resistance to taxan-based chemotherapy in pations with gastric cancer<ref>PMID:17611652</ref>.
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The expression of MAGE-A1 can be a marker for the prediction of resistance to taxan-based chemotherapy in pations with gastric cancer<ref>PMID:17611652</ref>. Assessment of MAGE may provide statification factor for active-specific immunotherapy<ref>PMID:12543800</ref>.
== Structural highlights ==
== Structural highlights ==

Revision as of 08:39, 16 April 2024

Human MAGEA4 MAGE homology domain (grey) complex with peptide inhibitor (green), ethanediol, ethylene glycol and TRIS (PDB id 7uoa)

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References

  1. Kirkin AF, Dzhandzhugazyan K, Zeuthen J. Melanoma-associated antigens recognized by cytotoxic T lymphocytes. APMIS. 1998 Jul;106(7):665-79. PMID:9740504 doi:10.1111/j.1699-0463.1998.tb00210.x
  2. Xiao J, Chen HS. Biological functions of melanoma-associated antigens. World J Gastroenterol. 2004 Jul 1;10(13):1849-53. PMID:15222021 doi:10.3748/wjg.v10.i13.1849
  3. Suzuki T, Yoshida K, Wada Y, Hamai Y, Sentani K, Oue N, Yasui W. Melanoma-associated antigen-A1 expression predicts resistance to docetaxel and paclitaxel in advanced and recurrent gastric cancer. Oncol Rep. 2007 Aug;18(2):329-36 PMID:17611652
  4. Takeuchi H, Kuo C, Morton DL, Wang HJ, Hoon DS. Expression of differentiation melanoma-associated antigen genes is associated with favorable disease outcome in advanced-stage melanomas. Cancer Res. 2003 Jan 15;63(2):441-8 PMID:12543800

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Michal Harel, Alexander Berchansky

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