Melanoma-associated antigen
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''Melanoma-associated antigen''' (MAGE) are produced by tumor cells and are recognized by cytotoxic T lymphocytes<ref>PMID:9740504</ref>. Many such antigens have been identified and are classified into 2 groups with group I called cancer/testis antigens<ref>PMID:15222021</ref>. | + | '''Melanoma-associated antigen''' (MAGE) are produced by tumor cells and are recognized by cytotoxic T lymphocytes<ref>PMID:9740504</ref>. Many such antigens have been identified and are classified into 2 groups with group I called cancer/testis antigens<ref>PMID:15222021</ref>. The loss of MAGE expression is observed in primary melanoma<ref>PMID:14676635</ref>. |
== Disease == | == Disease == | ||
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== Relevance == | == Relevance == | ||
| - | The expression of MAGE-A1 can be a marker for the prediction of resistance to taxan-based chemotherapy in pations with gastric cancer<ref>PMID:17611652</ref>. Assessment of MAGE may provide | + | The expression of MAGE-A1 can be a marker for the prediction of resistance to taxan-based chemotherapy in pations with gastric cancer<ref>PMID:17611652</ref>. Assessment of MAGE may provide stratification factor for active-specific immunotherapy<ref>PMID:12543800</ref>. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 08:48, 16 April 2024
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References
- ↑ Kirkin AF, Dzhandzhugazyan K, Zeuthen J. Melanoma-associated antigens recognized by cytotoxic T lymphocytes. APMIS. 1998 Jul;106(7):665-79. PMID:9740504 doi:10.1111/j.1699-0463.1998.tb00210.x
- ↑ Xiao J, Chen HS. Biological functions of melanoma-associated antigens. World J Gastroenterol. 2004 Jul 1;10(13):1849-53. PMID:15222021 doi:10.3748/wjg.v10.i13.1849
- ↑ Hofbauer GF, Burkhart A, Schüler G, Dummer R, Burg G, Nestle FO. High frequency of melanoma-associated antigen or HLA class I loss does not correlate with survival in primary melanoma. J Immunother. 2004 Jan-Feb;27(1):73-8. PMID:14676635 doi:10.1097/00002371-200401000-00007
- ↑ Suzuki T, Yoshida K, Wada Y, Hamai Y, Sentani K, Oue N, Yasui W. Melanoma-associated antigen-A1 expression predicts resistance to docetaxel and paclitaxel in advanced and recurrent gastric cancer. Oncol Rep. 2007 Aug;18(2):329-36 PMID:17611652
- ↑ Takeuchi H, Kuo C, Morton DL, Wang HJ, Hoon DS. Expression of differentiation melanoma-associated antigen genes is associated with favorable disease outcome in advanced-stage melanomas. Cancer Res. 2003 Jan 15;63(2):441-8 PMID:12543800
