User:Merritt Jugo/Sandbox 1
From Proteopedia
(Difference between revisions)
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You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | You may include any references to papers as in: the use of JSmol in Proteopedia <ref>DOI 10.1002/ijch.201300024</ref> or to the article describing Jmol <ref>PMID:21638687</ref> to the rescue. | ||
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| - | ==Introduction== | ||
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| - | ==Function== | ||
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| - | [[Image:DPP4_structure_wiki.png|200 px|right|thumb|Figure 1. DPPIV structure]] | ||
| - | DPPIV, a [http://www.en.wikipedia.org/wiki/Protein_moonlighting moonlighting protein], has been implicated in many functions and diseases of the body including glucose metabolism, cardiovascular disease, the stress response, autoimmune diseases (ie HIV/AIDS), inflammation, and tumor biology. | ||
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| - | ===Catalytic Triad=== | ||
| - | The [https://en.wikipedia.org/wiki/Catalytic_triad#:~:text=A%20catalytic%20triad%20is%20a,lipases%20and%20β%2Dlactamases). Catalytic Triad] of DPP4 is Ser630, His740, Asp708. | ||
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| - | ===Mechanism=== | ||
| - | [[Image:DPPIV_Mech.png|400 px|right|thumb|Figure 2. DPPIV Mechanism]] | ||
| - | The mechanism for the truncation of GLP-1 using DPP4 is a covalent catalysis. 708 | ||
| - | 1st Nucleophile is Oxygen on Ser630 and the 2nd Nucleophile is water. | ||
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| - | ==Disease== | ||
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| - | ==Relevance== | ||
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| - | ==Structural highlights== | ||
<scene name='10/1037493/Starter_dppiv/1'>Starter DPPIV</scene> | <scene name='10/1037493/Starter_dppiv/1'>Starter DPPIV</scene> | ||
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| - | + | ==Structural highlights== | |
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cleavage site (dim gray) 1-55 | cleavage site (dim gray) 1-55 | ||
beta-propeller (tomato) 56-496 | beta-propeller (tomato) 56-496 | ||
cytosine rich (khaki) 351-506 | cytosine rich (khaki) 351-506 | ||
catalytic domain (medium sea green) 552-776 | catalytic domain (medium sea green) 552-776 | ||
| - | <scene name='10/1037493/Starter_dppiv_colors/ | + | <scene name='10/1037493/Starter_dppiv_colors/10'>Starter DPPIV movie with color</scene> |
homodimer A (lavender) and B (dim gray) | homodimer A (lavender) and B (dim gray) | ||
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</StructureSection> | </StructureSection> | ||
==References== | ==References== | ||
| - | <ref name="Deacon">PMID:30828317</ref> | ||
<references/> | <references/> | ||
Revision as of 13:29, 16 April 2024
Merritt's Take on DPPIV
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References
- ↑ Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
- ↑ Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
Student Contributors
- Merritt Jugo
