User:Camille Gaudet/Sandbox 1
From Proteopedia
(Difference between revisions)
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== General Structure == | == General Structure == | ||
| - | scene name='10/1037488/Gip-r_noligand_noantibody/ | + | scene name='10/1037488/Gip-r_noligand_noantibody/6'>GIP-R without GIP</scene> |
=== Subunit Architecture === | === Subunit Architecture === | ||
| - | <scene name='10/1037488/Gip-r_galpha-centered/ | + | <scene name='10/1037488/Gip-r_galpha-centered/4'>G Alpha Subunit</scene> |
| - | <scene name='10/1037488/Gip-r_gbeta-centered/ | + | <scene name='10/1037488/Gip-r_gbeta-centered/3'>G Beta Subunit</scene> |
| - | <scene name='10/1037488/Gip-r_ggamma-centered/ | + | <scene name='10/1037488/Gip-r_ggamma-centered/3'>G Gamma Subunit</scene> |
| - | <scene name='10/1037488/Gip-r_receptor-centered/ | + | <scene name='10/1037488/Gip-r_receptor-centered/4'>G-Protein Coupled Receptor</scene> |
=== Glucose-dependent Insulinotropic Polypeptide === | === Glucose-dependent Insulinotropic Polypeptide === | ||
| - | <scene name='10/1037488/Gip-bound/ | + | <scene name='10/1037488/Gip-bound/4'>Bound GIP</scene> |
=== Active Site === | === Active Site === | ||
| - | <scene name='10/1037488/Gip-y1-intrxn-still/ | + | <scene name='10/1037488/Gip-y1-intrxn-still/8'>Crucial Y1 Interaction</scene> |
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== Medical Relevance == | == Medical Relevance == | ||
=== Tirzepatide === | === Tirzepatide === | ||
| - | <scene name='10/1037488/Tirz-bound/ | + | <scene name='10/1037488/Tirz-bound/3'>Bound Tirzepatide</scene> |
[[Image:sequencealignmentAA.jpg|700 px|right|thumb|Figure 1. Sequence alignment of GLP-1, GIP, and Tirzepatide. Residues shown in black are found in all three amino acid sequences. Pink or red coloration denotes residues that are unique to GIP or GLP-1, respectively. The sequence of tirzepatide is colored accordingly, and residues differing from both GIP and GLP-1 are highlighted in blue.]] | [[Image:sequencealignmentAA.jpg|700 px|right|thumb|Figure 1. Sequence alignment of GLP-1, GIP, and Tirzepatide. Residues shown in black are found in all three amino acid sequences. Pink or red coloration denotes residues that are unique to GIP or GLP-1, respectively. The sequence of tirzepatide is colored accordingly, and residues differing from both GIP and GLP-1 are highlighted in blue.]] | ||
Revision as of 14:13, 16 April 2024
Glucose-dependent Insulinotropic Polypeptide Receptor
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References
- ↑ Sun B, Willard FS, Feng D, Alsina-Fernandez J, Chen Q, Vieth M, Ho JD, Showalter AD, Stutsman C, Ding L, Suter TM, Dunbar JD, Carpenter JW, Mohammed FA, Aihara E, Brown RA, Bueno AB, Emmerson PJ, Moyers JS, Kobilka TS, Coghlan MP, Kobilka BK, Sloop KW. Structural determinants of dual incretin receptor agonism by tirzepatide. Proc Natl Acad Sci U S A. 2022 Mar 29;119(13):e2116506119. PMID:35333651 doi:10.1073/pnas.2116506119
Student Contributors
- Camille Gaudet
