1rm8
From Proteopedia
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'''Crystal structure of the catalytic domain of MMP-16/MT3-MMP: Characterization of MT-MMP specific features''' | '''Crystal structure of the catalytic domain of MMP-16/MT3-MMP: Characterization of MT-MMP specific features''' | ||
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[[Category: Noel, A]] | [[Category: Noel, A]] | ||
[[Category: Sounni, N E.]] | [[Category: Sounni, N E.]] | ||
| - | [[Category: | + | [[Category: Batimastat]] |
| - | [[Category: | + | [[Category: Hydroxamate inhibitor]] |
| - | [[Category: | + | [[Category: Membrane type - matrix metalloproteinase]] |
| - | [[Category: | + | [[Category: Mmp-16]] |
| - | [[Category: | + | [[Category: Mt-mmp]] |
| - | [[Category: | + | [[Category: Mt3-mmp]] |
| - | [[Category: | + | [[Category: Protease]] |
| - | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:39:54 2008'' | |
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | |
Revision as of 04:39, 3 May 2008
Crystal structure of the catalytic domain of MMP-16/MT3-MMP: Characterization of MT-MMP specific features
Overview
Membrane-type matrix metalloproteinases (MT-MMPs) have attracted strong attention, because four of them can activate a key player in the tumor scenario, proMMP-2/progelatinase A. In addition to this indirect effect on the cellular environment, these MT-MMPs degrade extracellular matrix proteins, and their overproduction is associated with tumor growth. We have solved the structure of the catalytic domain (cd) of MT3-MMP/MMP-16 in complex with the hydroxamic acid inhibitor batimastat. CdMT3-MMP exhibits a classical MMP-fold with similarity to MT1-MMP. Nevertheless, it also shows unique properties such as a modified MT-specific loop and a closed S1' specificity pocket, which might help to design specific inhibitors. Some MT-MMP-specific features, derived from the crystal structures of MT-1-MMP determined previously and MT3-MMP, and revealed in recent mutagenesis experiments, explain the impaired interaction of the MT-MMPs with TIMP-1. Docking experiments with proMMP-2 show some exposed loops including the MT-loop of cdMT3-MMP involved in the interaction with the proMMP-2 prodomain in the activation encounter complex. This model might help to understand the experimentally proven importance of the MT-loop for the activation of proMMP-2.
About this Structure
1RM8 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Crystal structure of the catalytic domain of MMP-16/MT3-MMP: characterization of MT-MMP specific features., Lang R, Braun M, Sounni NE, Noel A, Frankenne F, Foidart JM, Bode W, Maskos K, J Mol Biol. 2004 Feb 6;336(1):213-25. PMID:14741217 Page seeded by OCA on Sat May 3 07:39:54 2008
