8q7e
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Structure of CUL9-RBX1 ubiquitin E3 ligase complex - hexameric assembly== | |
| - | + | <StructureSection load='8q7e' size='340' side='right'caption='[[8q7e]], [[Resolution|resolution]] 4.40Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8q7e]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Q7E OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Q7E FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.4Å</td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q7e FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q7e OCA], [https://pdbe.org/8q7e PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q7e RCSB], [https://www.ebi.ac.uk/pdbsum/8q7e PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q7e ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/CUL9_HUMAN CUL9_HUMAN] Core component of a Cul9-RING ubiquitin-protein ligase complex, a complex that mediates ubiquitination and subsequent degradation of BIRC5 and is required to maintain microtubule dynamics and genome integrity. Acts downstream of the 3M complex, which inhibits CUL9 activity, leading to prevent ubiquitination of BIRC5 (PubMed:24793696). Cytoplasmic anchor protein in p53/TP53-associated protein complex. Regulates the subcellular localization of p53/TP53 and subsequent function (PubMed:12526791, PubMed:17332328).<ref>PMID:12526791</ref> <ref>PMID:17332328</ref> <ref>PMID:24793696</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Hopf LVM]] | ||
| + | [[Category: Horn-Ghetko D]] | ||
| + | [[Category: Schulman BA]] | ||
Revision as of 05:28, 17 April 2024
Structure of CUL9-RBX1 ubiquitin E3 ligase complex - hexameric assembly
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