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8q7v

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'''Unreleased structure'''
 
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The entry 8q7v is ON HOLD until Paper Publication
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==Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1)==
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<StructureSection load='8q7v' size='340' side='right'caption='[[8q7v]], [[Resolution|resolution]] 3.80&Aring;' scene=''>
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Authors: Riabov Bassat, D., Plaschka, C., Vorlaender, M.K.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8q7v]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Q7V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Q7V FirstGlance]. <br>
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Description: Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1)
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.8&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GTP:GUANOSINE-5-TRIPHOSPHATE'>GTP</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr>
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[[Category: Plaschka, C]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q7v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q7v OCA], [https://pdbe.org/8q7v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q7v RCSB], [https://www.ebi.ac.uk/pdbsum/8q7v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q7v ProSAT]</span></td></tr>
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[[Category: Riabov Bassat, D]]
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</table>
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[[Category: Vorlaender, M.K]]
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== Disease ==
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[https://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN] Defects in PRPF8 are the cause of retinitis pigmentosa type 13 (RP13) [MIM:[https://omim.org/entry/600059 600059]. RP leads to degeneration of retinal photoreceptor cells. Patients typically have night vision blindness and loss of midperipheral visual field. As their condition progresses, they lose their far peripheral visual field and eventually central vision as well. RP13 inheritance is autosomal dominant.<ref>PMID:17317632</ref> <ref>PMID:11468273</ref> [:]<ref>PMID:11910553</ref> <ref>PMID:12714658</ref>
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== Function ==
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[https://www.uniprot.org/uniprot/PRP8_HUMAN PRP8_HUMAN] Central component of the spliceosome, which may play a role in aligning the pre-mRNA 5'- and 3'-exons for ligation. Interacts with U5 snRNA, and with pre-mRNA 5'-splice sites in B spliceosomes and 3'-splice sites in C spliceosomes.
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Plaschka C]]
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[[Category: Riabov Bassat D]]
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[[Category: Vorlaender MK]]

Revision as of 05:28, 17 April 2024

Structure of the recycling U5 snRNP bound to chaperones CD2BP2 and TSSC4 (State 1)

PDB ID 8q7v

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