8y6i
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in nanodisc== | |
| - | + | <StructureSection load='8y6i' size='340' side='right'caption='[[8y6i]], [[Resolution|resolution]] 2.54Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[8y6i]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Y6I OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Y6I FirstGlance]. <br> | |
| - | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.54Å</td></tr> | |
| - | [[Category: | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3PE:1,2-DIACYL-SN-GLYCERO-3-PHOSPHOETHANOLAMINE'>3PE</scene>, <scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=R0Z:elacridar'>R0Z</scene></td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8y6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8y6i OCA], [https://pdbe.org/8y6i PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8y6i RCSB], [https://www.ebi.ac.uk/pdbsum/8y6i PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8y6i ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Disease == | ||
| + | [https://www.uniprot.org/uniprot/MDR1_HUMAN MDR1_HUMAN] Ulcerative colitis. Disease susceptibility is associated with variations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [https://www.uniprot.org/uniprot/A0A1S4NYF2_BRALA A0A1S4NYF2_BRALA] [https://www.uniprot.org/uniprot/MDR1_HUMAN MDR1_HUMAN] Energy-dependent efflux pump responsible for decreased drug accumulation in multidrug-resistant cells. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
| + | [[Category: Large Structures]] | ||
| + | [[Category: Mus musculus]] | ||
| + | [[Category: Adachi N]] | ||
| + | [[Category: Anzai N]] | ||
| + | [[Category: Hamaguchi-Suzuki N]] | ||
| + | [[Category: Kawasaki M]] | ||
| + | [[Category: Moriya T]] | ||
| + | [[Category: Murata T]] | ||
| + | [[Category: Senda T]] | ||
| + | [[Category: Suzuki K]] | ||
Revision as of 05:31, 17 April 2024
P-glycoprotein in complex with UIC2 Fab and triple elacridar molecules in nanodisc
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Categories: Homo sapiens | Large Structures | Mus musculus | Adachi N | Anzai N | Hamaguchi-Suzuki N | Kawasaki M | Moriya T | Murata T | Senda T | Suzuki K
