1rng

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[[Image:1rng.gif|left|200px]]
[[Image:1rng.gif|left|200px]]
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{{Structure
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|PDB= 1rng |SIZE=350|CAPTION= <scene name='initialview01'>1rng</scene>
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The line below this paragraph, containing "STRUCTURE_1rng", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=C:CYTIDINE-5&#39;-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5&#39;-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=U:URIDINE-5&#39;-MONOPHOSPHATE'>U</scene>
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{{STRUCTURE_1rng| PDB=1rng | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rng FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rng OCA], [http://www.ebi.ac.uk/pdbsum/1rng PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rng RCSB]</span>
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'''SOLUTION STRUCTURE OF THE CUUG HAIRPIN: A NOVEL RNA TETRALOOP MOTIF'''
'''SOLUTION STRUCTURE OF THE CUUG HAIRPIN: A NOVEL RNA TETRALOOP MOTIF'''
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==About this Structure==
==About this Structure==
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1RNG is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ ]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RNG OCA].
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1RNG OCA].
==Reference==
==Reference==
Solution structure of the CUUG hairpin loop: a novel RNA tetraloop motif., Jucker FM, Pardi A, Biochemistry. 1995 Nov 7;34(44):14416-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7578046 7578046]
Solution structure of the CUUG hairpin loop: a novel RNA tetraloop motif., Jucker FM, Pardi A, Biochemistry. 1995 Nov 7;34(44):14416-27. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7578046 7578046]
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[[Category: Protein complex]]
 
[[Category: Jucker, F M.]]
[[Category: Jucker, F M.]]
[[Category: Pardi, A.]]
[[Category: Pardi, A.]]
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[[Category: nmr]]
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[[Category: Nmr]]
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[[Category: rna]]
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[[Category: Rna]]
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[[Category: tetraloop]]
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[[Category: Tetraloop]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:42:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:30:28 2008''
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Revision as of 04:42, 3 May 2008

Image:1rng.gif

Template:STRUCTURE 1rng

SOLUTION STRUCTURE OF THE CUUG HAIRPIN: A NOVEL RNA TETRALOOP MOTIF


Overview

The solution structure of a uniformly 13C/15N-labeled CUUG RNA hairpin loop has been determined by multidimensional heteronuclear magnetic resonance spectroscopy in combination with distance geometry and restrained molecular dynamics calculations. The structure of this CUUG tetraloop represents a novel RNA loop motif where the first and last loop nucleotides form a standard Watson-Crick C-G base pair and the second loop nucleotide interacts directly with the closing base pair of the stem by folding into the minor groove. This structure helps explain why the closing base pair is phylogenetically conserved and indicates a six-nucleotide G(CUNG)C motif for the CUUG RNA tetraloop. Implications for the function of this CUUG tetraloop in ribosomal RNA and in RNA tertiary interactions are discussed.

About this Structure

Full crystallographic information is available from OCA.

Reference

Solution structure of the CUUG hairpin loop: a novel RNA tetraloop motif., Jucker FM, Pardi A, Biochemistry. 1995 Nov 7;34(44):14416-27. PMID:7578046 Page seeded by OCA on Sat May 3 07:42:02 2008

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