1u6q

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(New page: 200px<br /> <applet load="1u6q" size="450" color="white" frame="true" align="right" spinBox="true" caption="1u6q, resolution 2.02&Aring;" /> '''Substituted 2-Napht...)
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Revision as of 17:25, 12 November 2007

Image:1u6q.gif

1u6q, resolution 2.02Å

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Substituted 2-Naphthamadine inhibitors of Urokinase

Contents

Overview

A series of non-amide-linked 6-substituted-2-naphthamidine urokinase, plasminogen activator (uPA) inhibitors are described. These compounds, possess excellent binding activities and selectivities with significantly, improved pharmacokinetic profiles versus previously described amide-linked, inhibitors.

Disease

Known disease associated with this structure: Alzheimer disease, late-onset, susceptibility to OMIM:[191840]

About this Structure

1U6Q is a Single protein structure of sequence from Homo sapiens with 745 as ligand. Active as U-plasminogen activator, with EC number 3.4.21.73 Full crystallographic information is available from OCA.

Reference

Naphthamidine urokinase plasminogen activator inhibitors with improved pharmacokinetic properties., Bruncko M, McClellan WJ, Wendt MD, Sauer DR, Geyer A, Dalton CR, Kaminski MA, Weitzberg M, Gong J, Dellaria JF, Mantei R, Zhao X, Nienaber VL, Stewart K, Klinghofer V, Bouska J, Rockway TW, Giranda VL, Bioorg Med Chem Lett. 2005 Jan 3;15(1):93-8. PMID:15582418

Page seeded by OCA on Mon Nov 12 19:32:12 2007

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