1pvj
From Proteopedia
(Difference between revisions)
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<StructureSection load='1pvj' size='340' side='right'caption='[[1pvj]], [[Resolution|resolution]] 3.00Å' scene=''> | <StructureSection load='1pvj' size='340' side='right'caption='[[1pvj]], [[Resolution|resolution]] 3.00Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[1pvj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[1pvj]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Streptococcus_pyogenes Streptococcus pyogenes]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1PVJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1PVJ FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3Å</td></tr> |
| - | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZFB:(3R)-3-{[(BENZYLOXY)CARBONYL]AMINO}-2-OXO-4-PHENYLBUTANE-1-DIAZONIUM'>ZFB</scene></td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pvj OCA], [https://pdbe.org/1pvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pvj RCSB], [https://www.ebi.ac.uk/pdbsum/1pvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pvj ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1pvj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1pvj OCA], [https://pdbe.org/1pvj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1pvj RCSB], [https://www.ebi.ac.uk/pdbsum/1pvj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1pvj ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/SPEB_STRPY SPEB_STRPY] Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.<ref>PMID:9864206</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: Micrococcus scarlatinae klein 1884]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: | + | [[Category: Streptococcus pyogenes]] |
| - | [[Category: Cygler | + | [[Category: Cygler M]] |
| - | [[Category: Doran | + | [[Category: Doran J]] |
| - | [[Category: Menard | + | [[Category: Menard R]] |
| - | [[Category: Sivaraman | + | [[Category: Sivaraman J]] |
| - | [[Category: Ziomek | + | [[Category: Ziomek E]] |
| - | + | ||
| - | + | ||
Revision as of 05:59, 17 April 2024
Crystal structure of the Streptococcal pyrogenic exotoxin B (SpeB)- inhibitor complex
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