Melanoma-associated antigen

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 14: Line 14:
== Structural highlights ==
== Structural highlights ==
-
The 3D structure of the complex between MAGE-A4 and the peptide inhibitor shows the peptide to bind in a cyclic conformation. The <scene name='10/1042609/Cv/3'>peptide is anchored by 3 of its residues</scene> interacting with MAGE hydrophobic pocket. MAGE residue <scene name='10/1042609/Cv/4'>M161 makes Met-aromatic interactions with 2 of the peptide Tyr residues</scene>. Additional H-bonds are formed between the peptide inhibitor and MAGE<ref>PMID:35522528</ref>.
+
The 3D structure of the complex between MAGE-A4 and the peptide inhibitor shows the peptide to bind in a cyclic conformation. The <scene name='10/1042609/Cv/3'>peptide is anchored by 3 of its residues</scene> interacting with MAGE hydrophobic pocket. MAGE residue <scene name='10/1042609/Cv/5'>M161 makes Met-aromatic interactions with 2 of the peptide Tyr residues</scene>. Additional H-bonds are formed between the peptide inhibitor and MAGE<ref>PMID:35522528</ref>.
==3D structures of melanoma-associated antigen==
==3D structures of melanoma-associated antigen==

Revision as of 11:32, 17 April 2024

Human MAGEA4 MAGE homology domain (grey) complex with peptide inhibitor (green), ethanediol, ethylene glycol and TRIS (PDB id 7uoa)

Drag the structure with the mouse to rotate

References

  1. ↑ Kirkin AF, Dzhandzhugazyan K, Zeuthen J. Melanoma-associated antigens recognized by cytotoxic T lymphocytes. APMIS. 1998 Jul;106(7):665-79. PMID:9740504 doi:10.1111/j.1699-0463.1998.tb00210.x
  2. ↑ Xiao J, Chen HS. Biological functions of melanoma-associated antigens. World J Gastroenterol. 2004 Jul 1;10(13):1849-53. PMID:15222021 doi:10.3748/wjg.v10.i13.1849
  3. ↑ Hofbauer GF, Burkhart A, Schüler G, Dummer R, Burg G, Nestle FO. High frequency of melanoma-associated antigen or HLA class I loss does not correlate with survival in primary melanoma. J Immunother. 2004 Jan-Feb;27(1):73-8. PMID:14676635 doi:10.1097/00002371-200401000-00007
  4. ↑ Suzuki T, Yoshida K, Wada Y, Hamai Y, Sentani K, Oue N, Yasui W. Melanoma-associated antigen-A1 expression predicts resistance to docetaxel and paclitaxel in advanced and recurrent gastric cancer. Oncol Rep. 2007 Aug;18(2):329-36 PMID:17611652
  5. ↑ Takeuchi H, Kuo C, Morton DL, Wang HJ, Hoon DS. Expression of differentiation melanoma-associated antigen genes is associated with favorable disease outcome in advanced-stage melanomas. Cancer Res. 2003 Jan 15;63(2):441-8 PMID:12543800
  6. ↑ Fleming MC, Chiou LF, Tumbale PP, Droby GN, Lim J, Norris-Drouin JL, Williams JG, Pearce KH, Williams RS, Vaziri C, Bowers AA. Discovery and Structural Basis of the Selectivity of Potent Cyclic Peptide Inhibitors of MAGE-A4. J Med Chem. 2022 May 26;65(10):7231-7245. doi: 10.1021/acs.jmedchem.2c00185. Epub, 2022 May 6. PMID:35522528 doi:http://dx.doi.org/10.1021/acs.jmedchem.2c00185

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

Retrieved from "http://52.214.119.220/wiki/index.php/Melanoma-associated_antigen"
Personal tools