User:Karisma Moll/Sandbox 1

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will insert something to go with saxagliptin scene below:
will insert something to go with saxagliptin scene below:
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<scene name='10/1037489/Sax_interactions_wip/1'>sax interactions wip</scene>
 
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<scene name='10/1037489/Sax_intxn_labeled/1'>Sax inxtn lab</scene>
 
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<scene name='10/1037489/Sax_intxn/1'>sax intxn</scene>
 
<scene name='10/1037489/Vildagliptin_intxns/3'>new vild</scene>
<scene name='10/1037489/Vildagliptin_intxns/3'>new vild</scene>
<scene name='10/1037489/Sax_bonding/2'>scene caption sax bonding</scene>
<scene name='10/1037489/Sax_bonding/2'>scene caption sax bonding</scene>

Revision as of 13:18, 23 April 2024

Structure and Function of Dipeptidyl Peptidase IV (DPPIV) in Humans

PDB 6B1E for DPPIV in complex with Vildagliptin

Drag the structure with the mouse to rotate

References

  1. Ahrén B. DPP-4 Inhibition and the Path to Clinical Proof. Front Endocrinol (Lausanne). 2019 Jun 19;10:376. PMID:31275243 doi:10.3389/fendo.2019.00376
  2. Khalse M, Bhargava A. A Review on Cardiovascular Outcome Studies of Dipeptidyl Peptidase-4 Inhibitors. Indian J Endocrinol Metab. 2018 Sep-Oct;22(5):689-695. PMID:30294582 doi:10.4103/ijem.IJEM_104_18
  3. Hocher B, Reichetzeder C, Alter ML. Renal and cardiac effects of DPP4 inhibitors--from preclinical development to clinical research. Kidney Blood Press Res. 2012;36(1):65-84. PMID:22947920 doi:10.1159/000339028
  4. Zhong J, Rajagopalan S. Dipeptidyl Peptidase-4 Regulation of SDF-1/CXCR4 Axis: Implications for Cardiovascular Disease. Front Immunol. 2015 Sep 25;6:477. PMID:26441982 doi:10.3389/fimmu.2015.00477
  5. Sharma A, Ren X, Zhang H, Pandey GN. Effect of depression and suicidal behavior on neuropeptide Y (NPY) and its receptors in the adult human brain: A postmortem study. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jan 10;112:110428. PMID:34411658 doi:10.1016/j.pnpbp.2021.110428
  6. Ntafam CN, Beutler BD, Harris RD. Incarcerated gravid uterus: A rare but potentially devastating obstetric complication. Radiol Case Rep. 2022 Mar 10;17(5):1583-1586. PMID:35309386 doi:10.1016/j.radcr.2022.02.034
  7. 7.0 7.1 Hiramatsu H, Kyono K, Higashiyama Y, Fukushima C, Shima H, Sugiyama S, Inaka K, Yamamoto A, Shimizu R. The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold. Biochem Biophys Res Commun. 2003 Mar 21;302(4):849-54. PMID:12646248
  8. Abbott CA, McCaughan GW, Levy MT, Church WB, Gorrell MD. Binding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted beta propeller domain. Eur J Biochem. 1999 Dec;266(3):798-810. PMID:10583373 doi:10.1046/j.1432-1327.1999.00902.x
  9. Dobers J, Grams S, Reutter W, Fan H. Roles of cysteines in rat dipeptidyl peptidase IV/CD26 in processing and proteolytic activity. Eur J Biochem. 2000 Aug;267(16):5093-100. PMID:10931192 doi:10.1046/j.1432-1327.2000.01571.x
  10. Kim BR, Kim HY, Choi I, Kim JB, Jin CH, Han AR. DPP-IV Inhibitory Potentials of Flavonol Glycosides Isolated from the Seeds of Lens culinaris: In Vitro and Molecular Docking Analyses. Molecules. 2018 Aug 10;23(8):1998. PMID:30103438 doi:10.3390/molecules23081998
  11. Holst JJ. The physiology of glucagon-like peptide 1. Physiol Rev. 2007 Oct;87(4):1409-39. PMID:17928588 doi:10.1152/physrev.00034.2006
  12. Mulvihill EE, Drucker DJ. Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors. Endocr Rev. 2014 Dec;35(6):992-1019. PMID:25216328 doi:10.1210/er.2014-1035

Student Contributors

  • Karisma Moll
  • Merritt Jugo
  • Sam Magnabosco

Proteopedia Page Contributors and Editors (what is this?)

Karisma Moll

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