Sandbox Ben Whiteside

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 26: Line 26:
=== Bypass Motif ===
=== Bypass Motif ===
=== G-alpha Interactions with CTR TMD ===
=== G-alpha Interactions with CTR TMD ===
-
In order to transduce the signal across the cell membrane, the binding of amylin will induce a conformational change that allows for the CTR to make favorable interactions with the G alpha subunit. Two interactions shown <scene name='10/1038828/Ctr_g_alpha/15'>here </scene> and <scene name='10/1038828/Ctr_g_alpha/12'>here </scene> activate the G-protein and propel downstream signaling.
+
To transduce the signal across the cell membrane, the binding of amylin will induce a conformational change that allows for the CTR to make favorable interactions with the G alpha subunit. Two interactions shown <scene name='10/1038828/Ctr_g_alpha/15'>here </scene> and <scene name='10/1038828/Ctr_g_alpha/12'>here </scene> activate the G-protein and propel downstream signaling.
== Function ==
== Function ==
Line 32: Line 32:
== Relevance ==
== Relevance ==
 +
Line 41: Line 42:
== Student Contributors ==
== Student Contributors ==
-
Ben Whiteside,
+
Andrew Helmerich,Mathias Vander Eide, Ben Whiteside
-
Mathias Vander Eide,
+
-
Andrew Helmerich,
+

Revision as of 17:28, 23 April 2024

AMYR

AMYR Bound to Amylin

Drag the structure with the mouse to rotate

References

  1. Hanson, R. M., Prilusky, J., Renjian, Z., Nakane, T. and Sussman, J. L. (2013), JSmol and the Next-Generation Web-Based Representation of 3D Molecular Structure as Applied to Proteopedia. Isr. J. Chem., 53:207-216. doi:http://dx.doi.org/10.1002/ijch.201300024
  2. Herraez A. Biomolecules in the computer: Jmol to the rescue. Biochem Mol Biol Educ. 2006 Jul;34(4):255-61. doi: 10.1002/bmb.2006.494034042644. PMID:21638687 doi:10.1002/bmb.2006.494034042644
  3. Ransey E, Paredes E, Dey SK, Das SR, Heroux A, Macbeth MR. Crystal structure of the Entamoeba histolytica RNA lariat debranching enzyme EhDbr1 reveals a catalytic Zn(2+) /Mn(2+) heterobinucleation. FEBS Lett. 2017 Jul;591(13):2003-2010. doi: 10.1002/1873-3468.12677. Epub 2017, Jun 14. PMID:28504306 doi:http://dx.doi.org/10.1002/1873-3468.12677
  4. Cao J, Belousoff MJ, Liang YL, Johnson RM, Josephs TM, Fletcher MM, Christopoulos A, Hay DL, Danev R, Wootten D, Sexton PM. A structural basis for amylin receptor phenotype. Science. 2022 Mar 25;375(6587):eabm9609. PMID:35324283 doi:10.1126/science.abm9609


Student Contributors

Andrew Helmerich,Mathias Vander Eide, Ben Whiteside

Personal tools