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You may include any references to papers as in: the use of JSmol in Proteopedia ^[1] or to the article describing Jmol ^[2] to the rescue.

Introduction

Diabetes

Function

^[3].

Disease

Relevance

Structural highlights

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Binding/Active Site of GIPR with GIP

Figure 1. Residue Interactions with GIP

The of GIP with the GIP receptor (GIPR) is where the N-term of GIP binds with the transmembrane domain of the GIP receptor. This first interaction formed with GIPR and the N-term of GIP is a hydrogen bond between TYR1 and GLU224. The within the active site are forming hydrogen bonds with each other and activating the G-protein to start signaling.

Binding/Active Site of GIPR with Tirzepatide

Figure 2. Residue Interactions with Tirzepatide

The is the same as GIP with the N-term binding to the extracellular membrane. The are mostly the same just in a different conformation that is allowing for more hydrogen bonding.

Isoleucine vs. Threonine