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1u9x
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(New page: 200px<br /> <applet load="1u9x" size="450" color="white" frame="true" align="right" spinBox="true" caption="1u9x, resolution 2.1Å" /> '''Crystal Structure of...)
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Revision as of 17:26, 12 November 2007
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Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABJ688
Contents |
Overview
Starting from the high-throughput screening hit 1a, novel cathepsin K, inhibitors have been developed based on a purine scaffold. High-resolution, X-ray structures of several derivatives have revealed the binding mode of, these unique cysteine protease inhibitors.
Disease
Known disease associated with this structure: Pycnodysostosis OMIM:[601105]
About this Structure
1U9X is a Single protein structure of sequence from Homo sapiens with IHJ as ligand. Active as Cathepsin K, with EC number 3.4.22.38 Full crystallographic information is available from OCA.
Reference
Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K., Altmann E, Cowan-Jacob SW, Missbach M, J Med Chem. 2004 Nov 18;47(24):5833-6. PMID:15537340
Page seeded by OCA on Mon Nov 12 19:32:54 2007
