1rpq

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[[Image:1rpq.gif|left|200px]]
[[Image:1rpq.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1rpq |SIZE=350|CAPTION= <scene name='initialview01'>1rpq</scene>, resolution 3.00&Aring;
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The line below this paragraph, containing "STRUCTURE_1rpq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CIT:CITRIC+ACID'>CIT</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE= FCER1A, FCE1A ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens])
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-->
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|DOMAIN=
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{{STRUCTURE_1rpq| PDB=1rpq | SCENE= }}
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|RELATEDENTRY=[[1kco|1KCO]], [[1f2q|1F2Q]], [[1f6a|1F6A]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rpq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rpq OCA], [http://www.ebi.ac.uk/pdbsum/1rpq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rpq RCSB]</span>
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}}
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'''High Affinity IgE Receptor (alpha chain) Complexed with Tight-Binding E131 'zeta' Peptide from Phage Display'''
'''High Affinity IgE Receptor (alpha chain) Complexed with Tight-Binding E131 'zeta' Peptide from Phage Display'''
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[[Category: Starovasnik, M A.]]
[[Category: Starovasnik, M A.]]
[[Category: Yin, J P.]]
[[Category: Yin, J P.]]
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[[Category: receptor/peptide complex]]
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[[Category: Receptor/peptide complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:45:58 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:31:17 2008''
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Revision as of 04:45, 3 May 2008

Image:1rpq.gif

Template:STRUCTURE 1rpq

High Affinity IgE Receptor (alpha chain) Complexed with Tight-Binding E131 'zeta' Peptide from Phage Display


Overview

Two structurally distinct classes of peptides were recently identified by phage display that bind the high-affinity IgE receptor, FcepsilonRI, and block IgE binding and subsequent receptor activation. Both classes adopt highly stable structures in solution, one forming a beta hairpin, with the other forming a helical "zeta" structure. Despite these differences, the two classes bind competitively to the same site on the receptor. Structural analyses of both peptide-receptor complexes by NMR spectroscopy and/or X-ray crystallography reveal that the unrelated peptide scaffolds have nevertheless converged to present a similar three-dimensional surface to interact with FcepsilonRI and that their modes of interaction share a key feature of the IgE-FcepsilonRI complex, the proline/tryptophan sandwich.

About this Structure

1RPQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Convergent recognition of the IgE binding site on the high-affinity IgE receptor., Stamos J, Eigenbrot C, Nakamura GR, Reynolds ME, Yin J, Lowman HB, Fairbrother WJ, Starovasnik MA, Structure. 2004 Jul;12(7):1289-301. PMID:15242605 Page seeded by OCA on Sat May 3 07:45:58 2008

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OCA

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