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Basigin
From Proteopedia
(Difference between revisions)
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== Function == | == Function == | ||
| - | '''Basigin''' or '''CD147''' or '''EMMORIN''' is a transmembranal glycoprotein which is a receptor for a variety of proteins<ref>PMID:26684586</ref>. Basigin has several isoforms and contains immunoglobulin domains. | + | '''Basigin''' or '''CD147''' or '''EMMORIN''' is a transmembranal glycoprotein which is a receptor for a variety of proteins and is expressed by tumor cells<ref>PMID:26684586</ref>. Basigin has several isoforms and contains immunoglobulin-like domains (Ig-like). Alternative splicing of basigin results in 4 different isoforms. Basigin-2 is the most predominant form and contains 2 Ig-like domains. Basigin-1 contains 3 Ig-like domains, basigin-3 contains 1 Ig-like domain<ref>PMID:21536654</ref>. |
== Disease == | == Disease == | ||
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== Relevance == | == Relevance == | ||
| - | Basigin is involved in regulation of glycolysis and thus in development of malignant tumors and T-cell-mediated immunological disorders<ref>PMID:35844594</ref>. | + | Basigin is involved in regulation of glycolysis and thus in development of malignant tumors and T-cell-mediated immunological disorders<ref>PMID:35844594</ref>. Hence, basigin has been termed a cancer-associated biomarker and serves as a target for cancer therapy. |
== Structural highlights == | == Structural highlights == | ||
Revision as of 10:14, 30 April 2024
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References
- ↑ Muramatsu T. Basigin (CD147), a multifunctional transmembrane glycoprotein with various binding partners. J Biochem. 2016 May;159(5):481-90. PMID:26684586 doi:10.1093/jb/mvv127
- ↑ Liao CG, Kong LM, Song F, Xing JL, Wang LX, Sun ZJ, Tang H, Yao H, Zhang Y, Wang L, Wang Y, Yang XM, Li Y, Chen ZN. Characterization of basigin isoforms and the inhibitory function of basigin-3 in human hepatocellular carcinoma proliferation and invasion. Mol Cell Biol. 2011 Jul;31(13):2591-604. PMID:21536654 doi:10.1128/MCB.05160-11
- ↑ Xu Y, Chen Y, Zhang X, Ma J, Liu Y, Cui L, Wang F. Glycolysis in Innate Immune Cells Contributes to Autoimmunity. Front Immunol. 2022 Jul 1;13:920029. PMID:35844594 doi:10.3389/fimmu.2022.920029
