1ucp
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(New page: 200px<br /> <applet load="1ucp" size="450" color="white" frame="true" align="right" spinBox="true" caption="1ucp" /> '''NMR structure of the PYRIN domain of human ...)
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Revision as of 17:26, 12 November 2007
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NMR structure of the PYRIN domain of human ASC
Contents |
Overview
The PYRIN domain is a conserved sequence motif identified in more than 20, human proteins with putative functions in apoptotic and inflammatory, signalling pathways. The three-dimensional structure of the PYRIN domain, from human ASC was determined by NMR spectroscopy. The structure, determination reveals close structural similarity to death domains, death, effector domains, and caspase activation and recruitment domains, although, the structural alignment with these other members of the death-domain, superfamily differs from previously predicted amino acid sequence, alignments. Two highly positively and negatively charged surfaces in the, PYRIN domain of ASC result in a strong electrostatic dipole moment that is, predicted to be present also in related PYRIN domains. These results, suggest that electrostatic interactions play an important role for the, binding between PYRIN domains. Consequently, the previously reported, binding between the PYRIN domains of ASC and ASC2/POP1 or between the, zebrafish PYRIN domains of zAsc and Caspy is proposed to involve, interactions between helices 2 and 3 of one PYRIN domain with helices 1, and 4 of the other PYRIN domain, in analogy to previously reported, homophilic interactions between caspase activation and recruitment, domains.
Disease
Known diseases associated with this structure: Central hypoventilation syndrome, congenital OMIM:[100790], Haddad syndrome OMIM:[100790]
About this Structure
1UCP is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
The death-domain fold of the ASC PYRIN domain, presenting a basis for PYRIN/PYRIN recognition., Liepinsh E, Barbals R, Dahl E, Sharipo A, Staub E, Otting G, J Mol Biol. 2003 Oct 3;332(5):1155-63. PMID:14499617
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