1rra

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[[Image:1rra.jpg|left|200px]]
[[Image:1rra.jpg|left|200px]]
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{{Structure
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|PDB= 1rra |SIZE=350|CAPTION= <scene name='initialview01'>1rra</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1rra", creates the "Structure Box" on the page.
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|SITE=
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|LIGAND= <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span>
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{{STRUCTURE_1rra| PDB=1rra | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rra FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rra OCA], [http://www.ebi.ac.uk/pdbsum/1rra PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rra RCSB]</span>
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'''RIBONUCLEASE A FROM RATTUS NORVEGICUS (COMMON RAT)'''
'''RIBONUCLEASE A FROM RATTUS NORVEGICUS (COMMON RAT)'''
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[[Category: Salunke, D.]]
[[Category: Salunke, D.]]
[[Category: Wyns, L.]]
[[Category: Wyns, L.]]
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[[Category: hydrolase(phosphoric diester)]]
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[[Category: Ribonuclease]]
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[[Category: ribonuclease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:49:06 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:31:57 2008''
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Revision as of 04:49, 3 May 2008

Image:1rra.jpg

Template:STRUCTURE 1rra

RIBONUCLEASE A FROM RATTUS NORVEGICUS (COMMON RAT)


Overview

The three-dimensional structure of rat pancreatic RNase A expressed in Escherichia coli was determined. The backbone conformations of certain critical loops are significantly different in this enzyme compared to its bovine counterpart. However, the core structure of rat RNase A is similar to that of the other members of the pancreatic ribonuclease family. The structural variations within a loop bordering the active site can be correlated with the subtle differences in the enzymatic activities of bovine and rat ribonucleases for different substrates. The most significant difference in the backbone conformation was observed in the loop 15-25. This loop incorporates the subtilisin cleavage site which is responsible for RNase A to RNase S conversion in the bovine enzyme. The rat enzyme does not get cleaved under identical conditions. Molecular docking of this region of the rat enzyme in the active site of subtilisin shows steric incompatibility, although the bovine pancreatic ribonuclease A appropriately fits into this active site. It is therefore inferred that the local conformation of the substrate governs the specificity of subtilisin.

About this Structure

1RRA is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

The crystal structure of recombinant rat pancreatic RNase A., Gupta V, Muyldermans S, Wyns L, Salunke DM, Proteins. 1999 Apr 1;35(1):1-12. PMID:10090281 Page seeded by OCA on Sat May 3 07:49:06 2008

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