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8ugy

From Proteopedia

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Current revision (06:23, 1 May 2024) (edit) (undo)
 
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'''Unreleased structure'''
 
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The entry 8ugy is ON HOLD until Paper Publication
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==Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Mianserin==
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<StructureSection load='8ugy' size='340' side='right'caption='[[8ugy]], [[Resolution|resolution]] 3.31&Aring;' scene=''>
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Authors: Zilberg, G., Warren, A.L., Wacker, D.
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== Structural highlights ==
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<table><tr><td colspan='2'>[[8ugy]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8UGY OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8UGY FirstGlance]. <br>
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Description: Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Mianserin
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.31&#8491;</td></tr>
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[[Category: Unreleased Structures]]
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CLR:CHOLESTEROL'>CLR</scene>, <scene name='pdbligand=WRU:Mianserin'>WRU</scene></td></tr>
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[[Category: Wacker, D]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ugy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ugy OCA], [https://pdbe.org/8ugy PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ugy RCSB], [https://www.ebi.ac.uk/pdbsum/8ugy PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ugy ProSAT]</span></td></tr>
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[[Category: Warren, A.L]]
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</table>
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[[Category: Zilberg, G]]
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== Function ==
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[https://www.uniprot.org/uniprot/5HT1E_HUMAN 5HT1E_HUMAN] G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.<ref>PMID:14744596</ref> <ref>PMID:1513320</ref> <ref>PMID:1608964</ref> <ref>PMID:1733778</ref> <ref>PMID:21422162</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Homo sapiens]]
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[[Category: Large Structures]]
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[[Category: Wacker D]]
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[[Category: Warren AL]]
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[[Category: Zilberg G]]

Current revision

Serotonin 1E receptor (5-HT1eR)-Gi1 Complex bound with Mianserin

PDB ID 8ugy

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