1r9p

<StructureSection load='1r9p' size='340' side='right'caption='[[1r9p]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[1r9p]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacterium_influenzae"_lehmann_and_neumann_1896 "bacterium influenzae" lehmann and neumann 1896]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1R9P OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol=1R9P FirstGlance]. <br>

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[1q48|1q48]]</div></td></tr>

<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">HI0377 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=727 "Bacterium influenzae" Lehmann and Neumann 1896])</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=1r9p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1r9p OCA], [http://pdbe.org/1r9p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1r9p RCSB], [http://www.ebi.ac.uk/pdbsum/1r9p PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1r9p ProSAT], [http://www.topsan.org/Proteins/NESGC/1r9p TOPSAN]</span></td></tr>

[[http://www.uniprot.org/uniprot/ISCU_HAEIN ISCU_HAEIN]] A scaffold on which IscS assembles Fe-S clusters. Subsequently gives the nascent cluster to other proteins. It is likely that Fe-S cluster coordination is flexible as the role of this complex is to build and then hand off Fe-S clusters (By similarity).

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== Publication Abstract from PubMed ==

IscU is a highly conserved protein that serves as the scaffold for IscS-mediated assembly of iron-sulfur ([Fe-S]) clusters. We report the NMR solution structure of monomeric Haemophilus influenzae IscU with zinc bound at the [Fe-S] cluster assembly site. The compact core of the globular structure has an alpha-beta sandwich architecture with a three-stranded antiparallel beta-sheet and four alpha-helices. A nascent helix is located N-terminal to the core structure. The zinc is ligated by three cysteine residues and one histidine residue that are located in and near conformationally dynamic loops at one end of the IscU structure. Removal of the zinc metal by chelation results in widespread loss of structure in the apo form. The zinc-bound IscU may be a good model for iron-loaded IscU and may demonstrate structural features found in the [Fe-S] cluster bound form. Structural and functional similarities, genomic context in operons containing other homologous genes, and distributions of conserved surface residues support the hypothesis that IscU protein domains are homologous (i.e. derived from a common ancestor) with the SufE/YgdK family of [Fe-S] cluster assembly proteins.

Solution NMR structure of the iron-sulfur cluster assembly protein U (IscU) with zinc bound at the active site.,Ramelot TA, Cort JR, Goldsmith-Fischman S, Kornhaber GJ, Xiao R, Shastry R, Acton TB, Honig B, Montelione GT, Kennedy MA J Mol Biol. 2004 Nov 19;344(2):567-83. PMID:15522305<ref>PMID:15522305</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

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<div class="pdbe-citations 1r9p" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Bacterium influenzae lehmann and neumann 1896]]

[[Category: Acton, T B]]

[[Category: Cort, J R]]

[[Category: Kennedy, M A]]

[[Category: Montelione, G T]]

[[Category: Structural genomic]]

[[Category: Ramelot, T A]]

[[Category: Shastry, R]]

[[Category: Xiao, R]]

[[Category: Zinc binding]]