1rsg

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[[Image:1rsg.gif|left|200px]]
[[Image:1rsg.gif|left|200px]]
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{{Structure
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|PDB= 1rsg |SIZE=350|CAPTION= <scene name='initialview01'>1rsg</scene>, resolution 1.90&Aring;
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The line below this paragraph, containing "STRUCTURE_1rsg", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Polyamine_oxidase Polyamine oxidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.5.3.11 1.5.3.11] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE= FMS1, YMR020W, YM9711.09 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 Saccharomyces cerevisiae])
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|DOMAIN=
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{{STRUCTURE_1rsg| PDB=1rsg | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rsg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rsg OCA], [http://www.ebi.ac.uk/pdbsum/1rsg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rsg RCSB]</span>
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}}
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'''Crystal structure of the polyamine oxidase Fms1 from yeast'''
'''Crystal structure of the polyamine oxidase Fms1 from yeast'''
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[[Category: Huang, Q.]]
[[Category: Huang, Q.]]
[[Category: Liu, Q.]]
[[Category: Liu, Q.]]
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[[Category: fad binding motif]]
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[[Category: Fad binding motif]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:51:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:32:18 2008''
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Revision as of 04:51, 3 May 2008

Image:1rsg.gif

Template:STRUCTURE 1rsg

Crystal structure of the polyamine oxidase Fms1 from yeast


Overview

Fms1 is a rate-limiting enzyme for the biosynthesis of pantothenic acid in yeast. Fms1 has polyamine oxidase (PAO) activity, which converts spermine into spermidine and 3-aminopropanal. The 3-aminopropanal is further oxidized to produce beta-alanine, which is necessary for the biosynthesis of pantothenic acid. The crystal structures of Fms1 and its complex with the substrate spermine have been determined using the single-wavelength anomalous diffraction (SAD) phasing method. Fms1 consists of an FAD-binding domain, with Rossmann fold topology, and a substrate-binding domain. The active site is a tunnel located at the interface of the two domains. The substrate spermine binds to the active site mainly via hydrogen bonds and hydrophobic interactions. In the complex, C11 but not C9 of spermine is close enough to the catalytic site (N5 of FAD) to be oxidized. Therefore, the products are spermidine and 3-aminopropanal, rather than 3-(aminopropyl) 4-aminobutyraldehyde and 1,3-diaminoprone.

About this Structure

1RSG is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Crystal structures of Fms1 and its complex with spermine reveal substrate specificity., Huang Q, Liu Q, Hao Q, J Mol Biol. 2005 May 13;348(4):951-9. PMID:15843025 Page seeded by OCA on Sat May 3 07:51:26 2008

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