2jwe
From Proteopedia
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==Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping== | ==Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping== | ||
| - | <StructureSection load='2jwe' size='340' side='right'caption='[[2jwe | + | <StructureSection load='2jwe' size='340' side='right'caption='[[2jwe]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2jwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2jwe]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2JWE OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2JWE FirstGlance]. <br> |
| - | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwe OCA], [https://pdbe.org/2jwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jwe RCSB], [https://www.ebi.ac.uk/pdbsum/2jwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwe ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2jwe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2jwe OCA], [https://pdbe.org/2jwe PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2jwe RCSB], [https://www.ebi.ac.uk/pdbsum/2jwe PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2jwe ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | + | [https://www.uniprot.org/uniprot/ZO1_HUMAN ZO1_HUMAN] The N-terminal may be involved in transducing a signal required for tight junction assembly, while the C-terminal may have specific properties of tight junctions. The alpha domain might be involved in stabilizing junctions. Plays a role in the regulation of cell migration by targeting CDC42BPB to the leading edge of migrating cells.<ref>PMID:21240187</ref> | |
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Homo sapiens]] |
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Ji | + | [[Category: Ji P]] |
| - | [[Category: Shi | + | [[Category: Shi YY]] |
| - | [[Category: Wu | + | [[Category: Wu JH]] |
| - | [[Category: Wu | + | [[Category: Wu JW]] |
| - | [[Category: Yang | + | [[Category: Yang YS]] |
| - | [[Category: Zhang | + | [[Category: Zhang JH]] |
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Current revision
Solution structure of the second PDZ domain from human zonula occludens-1: A dimeric form with 3D domain swapping
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Categories: Homo sapiens | Large Structures | Ji P | Shi YY | Wu JH | Wu JW | Yang YS | Zhang JH
