2lze
From Proteopedia
(Difference between revisions)
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lze OCA], [https://pdbe.org/2lze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lze RCSB], [https://www.ebi.ac.uk/pdbsum/2lze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lze ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lze FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lze OCA], [https://pdbe.org/2lze PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lze RCSB], [https://www.ebi.ac.uk/pdbsum/2lze PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lze ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| - | <div style="background-color:#fffaf0;"> | ||
| - | == Publication Abstract from PubMed == | ||
| - | Engineering functional protein scaffolds capable of carrying out chemical catalysis is a major challenge in enzyme design. Starting from a noncatalytic protein scaffold, we recently generated a new RNA ligase by in vitro directed evolution. This artificial enzyme lost its original fold and adopted an entirely new structure with substantially enhanced conformational dynamics, demonstrating that a primordial fold with suitable flexibility is sufficient to carry out enzymatic function. | ||
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| - | Structure and dynamics of a primordial catalytic fold generated by in vitro evolution.,Chao FA, Morelli A, Iii JC, Churchfield L, Hagmann LN, Shi L, Masterson LR, Sarangi R, Veglia G, Seelig B Nat Chem Biol. 2012 Dec 9. doi: 10.1038/nchembio.1138. PMID:23222886<ref>PMID:23222886</ref> | ||
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| - | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
| - | </div> | ||
| - | <div class="pdbe-citations 2lze" style="background-color:#fffaf0;"></div> | ||
| - | == References == | ||
| - | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Current revision
Ligase 10C
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Categories: Large Structures | Synthetic construct | Chao F | Churchfield L | Hagmann L | Haugner J | Masterson L | Morelli A | Sarangi R | Seelig B | Shi L | Veglia G
