1rtb

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[[Image:1rtb.jpg|left|200px]]
[[Image:1rtb.jpg|left|200px]]
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{{Structure
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|PDB= 1rtb |SIZE=350|CAPTION= <scene name='initialview01'>1rtb</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1rtb", creates the "Structure Box" on the page.
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|SITE=
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Pancreatic_ribonuclease Pancreatic ribonuclease], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.27.5 3.1.27.5] </span>
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{{STRUCTURE_1rtb| PDB=1rtb | SCENE= }}
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rtb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rtb OCA], [http://www.ebi.ac.uk/pdbsum/1rtb PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rtb RCSB]</span>
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'''CRYSTAL STRUCTURE DISPOSITION OF THYMIDYLIC ACID TETRAMER IN COMPLEX WITH RIBONUCLEASE A'''
'''CRYSTAL STRUCTURE DISPOSITION OF THYMIDYLIC ACID TETRAMER IN COMPLEX WITH RIBONUCLEASE A'''
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[[Category: Birdsall, D L.]]
[[Category: Birdsall, D L.]]
[[Category: McPherson, A.]]
[[Category: McPherson, A.]]
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[[Category: hydrolase(nucleic acid,rna)]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:52:55 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:32:43 2008''
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Revision as of 04:52, 3 May 2008

Image:1rtb.jpg

Template:STRUCTURE 1rtb

CRYSTAL STRUCTURE DISPOSITION OF THYMIDYLIC ACID TETRAMER IN COMPLEX WITH RIBONUCLEASE A


Overview

The crystal structure of ribonuclease A with bound thymidylic acid tetramer is reported at 2.5-A resolution. The diffusion of the tetramer into native orthorhombic crystals of the ribonuclease allows for the formation of a structurally stable complex where the single-stranded nucleic acid enters and leaves the enzyme's catalytic region in a persistent 5'-3' direction. The binding of the tetramer to the enzyme's surface is facilitated and mediated by electrostatic interactions between basic protein residues and nucleotide phosphates. Two pyrimidine nucleotides are bound to the enzyme's active site in a manner similar to that observed for other complexes between ribonuclease A and nucleic acid oligomers.

About this Structure

1RTB is a Single protein structure of sequence from Bos taurus. Full crystallographic information is available from OCA.

Reference

Crystal structure disposition of thymidylic acid tetramer in complex with ribonuclease A., Birdsall DL, McPherson A, J Biol Chem. 1992 Nov 5;267(31):22230-6. PMID:1429575 Page seeded by OCA on Sat May 3 07:52:55 2008

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