2mxl

<StructureSection load='2mxl' size='340' side='right'caption='[[2mxl]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>

<table><tr><td colspan='2'>[[2mxl]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MXL FirstGlance]. <br>

</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mxl OCA], [https://pdbe.org/2mxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mxl RCSB], [https://www.ebi.ac.uk/pdbsum/2mxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mxl ProSAT]</span></td></tr>

<div style="background-color:#fffaf0;">

== Publication Abstract from PubMed ==

Influenza A is an RNA virus with a genome of eight negative sense segments. Segment 7 mRNA contains a 3' splice site for alternative splicing to code for essential M2 protein. On the basis of sequence alignment and chemical mapping experiments, the secondary structure surrounding the 3' splice site has an internal loop, adenine bulge, and hairpin loop when it is in the hairpin conformation that exposes the 3' splice site. We report structural features of a 3D model of the hairpin derived from NMR spectra and simulated annealing with restrained molecular dynamics. The internal loop containing the 3' splice site has a dynamic guanosine and a stable imino (cis Watson-Crick/Watson-Crick) GA pair. The adenine bulge also appears to be dynamic with the A either stacked in the stem or forming a base triple with a Watson-Crick GC pair. The hairpin loop is a GAAA tetraloop closed by an AC pair.

Structural features of a 3' splice site in influenza A.,Chen JL, Kennedy SD, Turner DH Biochemistry. 2015 Apr 24. PMID:25909229<ref>PMID:25909229</ref>

From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>

</div>

<div class="pdbe-citations 2mxl" style="background-color:#fffaf0;"></div>

== References ==

<references/>

[[Category: Chen, J L]]

[[Category: Kennedy, S D]]

[[Category: Turner, D H]]

[[Category: Influenza some]]

[[Category: Splice site]]