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1rtg

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[[Image:1rtg.jpg|left|200px]]
[[Image:1rtg.jpg|left|200px]]
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{{Structure
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<!--
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|PDB= 1rtg |SIZE=350|CAPTION= <scene name='initialview01'>1rtg</scene>, resolution 2.6&Aring;
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The line below this paragraph, containing "STRUCTURE_1rtg", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Gelatinase_A Gelatinase A], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.24 3.4.24.24] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1rtg| PDB=1rtg | SCENE= }}
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|RELATEDENTRY=
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rtg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rtg OCA], [http://www.ebi.ac.uk/pdbsum/1rtg PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rtg RCSB]</span>
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}}
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'''C-TERMINAL DOMAIN (HAEMOPEXIN-LIKE DOMAIN) OF HUMAN MATRIX METALLOPROTEINASE-2'''
'''C-TERMINAL DOMAIN (HAEMOPEXIN-LIKE DOMAIN) OF HUMAN MATRIX METALLOPROTEINASE-2'''
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[[Category: Bode, W.]]
[[Category: Bode, W.]]
[[Category: Gohlke, U.]]
[[Category: Gohlke, U.]]
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[[Category: gelatinase]]
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[[Category: Gelatinase]]
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[[Category: matrix metallo proteinase (mmp)]]
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[[Category: Metalloprotease]]
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[[Category: metalloprotease]]
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[[Category: Metzincin]]
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[[Category: metzincin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:53:13 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:32:42 2008''
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Revision as of 04:53, 3 May 2008

Image:1rtg.jpg

Template:STRUCTURE 1rtg

C-TERMINAL DOMAIN (HAEMOPEXIN-LIKE DOMAIN) OF HUMAN MATRIX METALLOPROTEINASE-2


Overview

In common with most other matrix metalloproteinases, gelatinase A has a non-catalytic C-terminal domain that displays sequence homology to haemopexin. Crystals of this domain were used by molecular replacement to solve its molecular structure at 2.6 A resolution, which was refined to an R value of 17.9%. This structure has a disc-like shape, with the chain folded into a beta-propeller structure that has pseudo four-fold symmetry. Although the topology and the side-chain arrangement are very similar to the equivalent domain of fibroblast collagenase, significant differences in surface charge and contouring are observable on 1 side of the gelatinase A disc. This difference might be a factor in allowing the gelatinase A C-terminal domain to bind to natural inhibitor TIMP-2.

About this Structure

1RTG is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The C-terminal (haemopexin-like) domain structure of human gelatinase A (MMP2): structural implications for its function., Gohlke U, Gomis-Ruth FX, Crabbe T, Murphy G, Docherty AJ, Bode W, FEBS Lett. 1996 Jan 8;378(2):126-30. PMID:8549817 Page seeded by OCA on Sat May 3 07:53:13 2008

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