This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1rtl

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
[[Image:1rtl.gif|left|200px]]
[[Image:1rtl.gif|left|200px]]
-
{{Structure
+
<!--
-
|PDB= 1rtl |SIZE=350|CAPTION= <scene name='initialview01'>1rtl</scene>, resolution 2.75&Aring;
+
The line below this paragraph, containing "STRUCTURE_1rtl", creates the "Structure Box" on the page.
-
|SITE=
+
You may change the PDB parameter (which sets the PDB file loaded into the applet)
-
|LIGAND= <scene name='pdbligand=CPX:N-[(2R,3S)-1-((2S)-2-{[(CYCLOPENTYLAMINO)CARBONYL]AMINO}-3-METHYLBUTANOYL)-2-(1-FORMYL-1-CYCLOBUTYL)PYRROLIDINYL]CYCLOPROPANECARBOXAMIDE'>CPX</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
+
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
-
|ACTIVITY=
+
or leave the SCENE parameter empty for the default display.
-
|GENE= H STRAIN ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
+
-->
-
|DOMAIN=
+
{{STRUCTURE_1rtl| PDB=1rtl | SCENE= }}
-
|RELATEDENTRY=[[1n1l|1N1L]]
+
-
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rtl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rtl OCA], [http://www.ebi.ac.uk/pdbsum/1rtl PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rtl RCSB]</span>
+
-
}}
+
'''CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN: NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND PYRROLIDINE-5,5-TRANSLACTAM INHIBITOR'''
'''CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN: NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND PYRROLIDINE-5,5-TRANSLACTAM INHIBITOR'''
Line 27: Line 24:
[[Category: Skarzynski, T.]]
[[Category: Skarzynski, T.]]
[[Category: Somers, D O.N.]]
[[Category: Somers, D O.N.]]
-
[[Category: cofactor peptide]]
+
[[Category: Cofactor peptide]]
-
[[Category: helicase]]
+
[[Category: Helicase]]
-
[[Category: inhibitor]]
+
[[Category: Inhibitor]]
-
[[Category: nonstructural protein]]
+
[[Category: Nonstructural protein]]
-
[[Category: serine protease]]
+
[[Category: Serine protease]]
-
[[Category: translactam]]
+
[[Category: Translactam]]
-
[[Category: viral protein]]
+
[[Category: Viral protein]]
-
 
+
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:53:27 2008''
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:32:45 2008''
+

Revision as of 04:53, 3 May 2008

Image:1rtl.gif

Template:STRUCTURE 1rtl

CRYSTAL STRUCTURE OF HCV NS3 PROTEASE DOMAIN: NS4A PEPTIDE COMPLEX WITH COVALENTLY BOUND PYRROLIDINE-5,5-TRANSLACTAM INHIBITOR


Overview

[reaction: see text] In this, the first of two Letters, we describe how a P3/P4 urea linking unit was used to greatly enhance the biochemical and replicon potency of inhibitors based upon the pyrrolidine-5,5-trans-lactam template. Compound 7b demonstrated a 100 nM IC(50) in the replicon cell-based surrogate HCV assay.

About this Structure

1RTL is a Protein complex structure of sequences from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Pyrrolidine-5,5-trans-lactams. 4. Incorporation of a P3/P4 urea leads to potent intracellular inhibitors of hepatitis C virus NS3/4A protease., Slater MJ, Amphlett EM, Andrews DM, Bamborough P, Carey SJ, Johnson MR, Jones PS, Mills G, Parry NR, Somers DO, Stewart AJ, Skarzynski T, Org Lett. 2003 Nov 27;5(24):4627-30. PMID:14627400 Page seeded by OCA on Sat May 3 07:53:27 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1rtl"
Personal tools