2rqh

From Proteopedia

(Difference between revisions)

Current revision

Structure of GSPT1/ERF3A-PABC

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2rqh"

@@ Line 1: / Line 1: @@
 ==Structure of GSPT1/ERF3A-PABC==
-<StructureSection load='2rqh' size='340' side='right'caption='[[2rqh]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='2rqh' size='340' side='right'caption='[[2rqh]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[2rqh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Human Human] and [https://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQH FirstGlance]. <br>
+<table><tr><td colspan='2'>[[2rqh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2RQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2RQH FirstGlance]. <br>
-</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2rqg|2rqg]]</div></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Gspt1 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10090 LK3 transgenic mice]), PABPC1, PAB1, PABP1, PABPC2 ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
 <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2rqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rqh OCA], [https://pdbe.org/2rqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2rqh RCSB], [https://www.ebi.ac.uk/pdbsum/2rqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2rqh ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[https://www.uniprot.org/uniprot/ERF3A_MOUSE ERF3A_MOUSE]] Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity). [[https://www.uniprot.org/uniprot/PABP1_HUMAN PABP1_HUMAN]] Binds the poly(A) tail of mRNA. May be involved in cytoplasmic regulatory processes of mRNA metabolism such as pre-mRNA splicing. Its function in translational initiation regulation can either be enhanced by PAIP1 or repressed by PAIP2. Can probably bind to cytoplasmic RNA sequences other than poly(A) in vivo. Involved in translationally coupled mRNA turnover. Implicated with other RNA-binding proteins in the cytoplasmic deadenylation/translational and decay interplay of the FOS mRNA mediated by the major coding-region determinant of instability (mCRD) domain. Involved in regulation of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons; for the recognition of premature termination codons (PTC) and initiation of NMD a competitive interaction between UPF1 and PABPC1 with the ribosome-bound release factors is proposed.<ref>PMID:11051545</ref> <ref>PMID:18447585</ref>
+[https://www.uniprot.org/uniprot/ERF3A_MOUSE ERF3A_MOUSE] Involved in translation termination in response to the termination codons UAA, UAG and UGA. Stimulates the activity of ERF1. Involved in regulation of mammalian cell growth. Component of the transient SURF complex which recruits UPF1 to stalled ribosomes in the context of nonsense-mediated decay (NMD) of mRNAs containing premature stop codons (By similarity).
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
@@ Line 20: / Line 19: @@
 </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2rqh ConSurf].
 <div style="clear:both"></div>
-== References ==
-<references/>
 __TOC__
 </StructureSection>
-[[Category: Human]]
+[[Category: Homo sapiens]]
 [[Category: Large Structures]]
-[[Category: Lk3 transgenic mice]]
+[[Category: Mus musculus]]
-[[Category: Hoshino, T]]
+[[Category: Hoshino T]]
-[[Category: Hosoda, N]]
+[[Category: Hosoda N]]
-[[Category: Katada, I]]
+[[Category: Katada I]]
-[[Category: Nakanishi, T]]
+[[Category: Nakanishi T]]
-[[Category: Osawa, M]]
+[[Category: Osawa M]]
-[[Category: Shimada, I]]
+[[Category: Shimada I]]
-[[Category: Uchida, S]]
+[[Category: Uchida S]]
-[[Category: Alternative splicing]]
-[[Category: Cytoplasm]]
-[[Category: Gtp-binding]]
-[[Category: Methylation]]
-[[Category: Mrna processing]]
-[[Category: Mrna splicing]]
-[[Category: Nucleotide-binding]]
-[[Category: Nucleus]]
-[[Category: Phosphoprotein]]
-[[Category: Protein binding]]
-[[Category: Protein-protein complex]]
-[[Category: Rna-binding]]
-[[Category: Spliceosome]]

2rqh

From Proteopedia

Current revision

Structure of GSPT1/ERF3A-PABC

Structural highlights

Function

Evolutionary Conservation

Contents

Proteopedia Page Contributors and Editors (what is this?)

Views

Personal tools

Navigation

Search

Toolbox