1rtq

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[[Image:1rtq.gif|left|200px]]
[[Image:1rtq.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1rtq |SIZE=350|CAPTION= <scene name='initialview01'>1rtq</scene>, resolution 0.95&Aring;
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The line below this paragraph, containing "STRUCTURE_1rtq", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=SCN:THIOCYANATE+ION'>SCN</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Bacterial_leucyl_aminopeptidase Bacterial leucyl aminopeptidase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.11.10 3.4.11.10] </span>
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1rtq| PDB=1rtq | SCENE= }}
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|RELATEDENTRY=[[1amp|1AMP]], [[1cp6|1CP6]], [[1ft7|1FT7]], [[1lok|1LOK]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rtq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rtq OCA], [http://www.ebi.ac.uk/pdbsum/1rtq PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rtq RCSB]</span>
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}}
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'''The 0.95 Angstrom Resolution Crystal Structure of the Aminopeptidase from Aeromonas proteolytica'''
'''The 0.95 Angstrom Resolution Crystal Structure of the Aminopeptidase from Aeromonas proteolytica'''
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[[Category: Petsko, G A.]]
[[Category: Petsko, G A.]]
[[Category: Ringe, D.]]
[[Category: Ringe, D.]]
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[[Category: aminopeptidase]]
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[[Category: Aminopeptidase]]
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[[Category: bimetallic]]
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[[Category: Bimetallic]]
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[[Category: high resolution]]
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[[Category: High resolution]]
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[[Category: zinc]]
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[[Category: Zinc]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:53:45 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:32:48 2008''
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Revision as of 04:53, 3 May 2008

Image:1rtq.gif

Template:STRUCTURE 1rtq

The 0.95 Angstrom Resolution Crystal Structure of the Aminopeptidase from Aeromonas proteolytica


Overview

The aminopeptidase from Aeromonas proteolytica (AAP) contains two zinc ions in the active site and catalyzes the degradation of peptides. Herein we report the crystal structures of AAP at 0.95-A resolution at neutral pH and at 1.24-A resolution at low pH. The combination of these structures allowed the precise modeling of atomic positions, the identification of the metal bridging oxygen species, and insight into the physical properties of the metal ions. On the basis of these structures, a new putative catalytic mechanism is proposed for AAP that is likely relevant to all binuclear metalloproteases.

About this Structure

1RTQ is a Single protein structure of sequence from Vibrio proteolyticus. Full crystallographic information is available from OCA.

Reference

The high-resolution structures of the neutral and the low pH crystals of aminopeptidase from Aeromonas proteolytica., Desmarais W, Bienvenue DL, Bzymek KP, Petsko GA, Ringe D, Holz RC, J Biol Inorg Chem. 2006 Jun;11(4):398-408. Epub 2006 Apr 5. PMID:16596389 Page seeded by OCA on Sat May 3 07:53:45 2008

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