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3zid

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Current revision (07:12, 1 May 2024) (edit) (undo)
 
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<StructureSection load='3zid' size='340' side='right'caption='[[3zid]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='3zid' size='340' side='right'caption='[[3zid]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3zid]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/"methanothrix_thermoacetophila"_nozhevnikova_and_chudina_1984 "methanothrix thermoacetophila" nozhevnikova and chudina 1984]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZID FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3zid]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Methanothrix_thermoacetophila Methanothrix thermoacetophila]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3ZID OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3ZID FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zid OCA], [https://pdbe.org/3zid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zid RCSB], [https://www.ebi.ac.uk/pdbsum/3zid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zid ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3zid FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3zid OCA], [https://pdbe.org/3zid PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3zid RCSB], [https://www.ebi.ac.uk/pdbsum/3zid PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3zid ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/CETZ_METTP CETZ_METTP] Involved in cell shape control.[HAMAP-Rule:MF_01946]
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Tubulin is a major component of the eukaryotic cytoskeleton, controlling cell shape, structure and dynamics, whereas its bacterial homologue FtsZ establishes the cytokinetic ring that constricts during cell division. How such different roles of tubulin and FtsZ evolved is unknown. Studying Archaea may provide clues as these organisms share characteristics with Eukarya and Bacteria. Here we report the structure and function of proteins from a distinct family related to tubulin and FtsZ, named CetZ, which co-exists with FtsZ in many archaea. CetZ X-ray crystal structures showed the FtsZ/tubulin superfamily fold, and one crystal form contained sheets of protofilaments, suggesting a structural role. However, inactivation of CetZ proteins in Haloferax volcanii did not affect cell division. Instead, CetZ1 was required for differentiation of the irregular plate-shaped cells into a rod-shaped cell type that was essential for normal swimming motility. CetZ1 formed dynamic cytoskeletal structures in vivo, relating to its capacity to remodel the cell envelope and direct rod formation. CetZ2 was also implicated in H. volcanii cell shape control. Our findings expand the known roles of the FtsZ/tubulin superfamily to include archaeal cell shape dynamics, suggesting that a cytoskeletal role might predate eukaryotic cell evolution, and they support the premise that a major function of the microbial rod shape is to facilitate swimming.
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CetZ tubulin-like proteins control archaeal cell shape.,Duggin IG, Aylett CH, Walsh JC, Michie KA, Wang Q, Turnbull L, Dawson EM, Harry EJ, Whitchurch CB, Amos LA, Lowe J Nature. 2014 Dec 22. doi: 10.1038/nature13983. PMID:25533961<ref>PMID:25533961</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 3zid" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Methanothrix thermoacetophila nozhevnikova and chudina 1984]]
 
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Amos, L A]]
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[[Category: Methanothrix thermoacetophila]]
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[[Category: Aylett, C H.S]]
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[[Category: Amos LA]]
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[[Category: Lowe, J]]
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[[Category: Aylett CHS]]
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[[Category: Cytoskeleton]]
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[[Category: Lowe J]]
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[[Category: Gtp-binding protein]]
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[[Category: Phuz]]
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[[Category: Tubz]]
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Current revision

CetZ from Methanosaeta thermophila strain DSM 6194

PDB ID 3zid

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