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6hxa

From Proteopedia

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Current revision (07:35, 1 May 2024) (edit) (undo)
 
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<StructureSection load='6hxa' size='340' side='right'caption='[[6hxa]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
<StructureSection load='6hxa' size='340' side='right'caption='[[6hxa]], [[Resolution|resolution]] 1.85&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[6hxa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6HXA FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6hxa]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Photorhabdus_luminescens Photorhabdus luminescens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6HXA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6HXA FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.85&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=6hxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxa OCA], [http://pdbe.org/6hxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=6hxa RCSB], [http://www.ebi.ac.uk/pdbsum/6hxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxa ProSAT]</span></td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=PG4:TETRAETHYLENE+GLYCOL'>PG4</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6hxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6hxa OCA], [https://pdbe.org/6hxa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6hxa RCSB], [https://www.ebi.ac.uk/pdbsum/6hxa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6hxa ProSAT]</span></td></tr>
</table>
</table>
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<div style="background-color:#fffaf0;">
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== Function ==
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== Publication Abstract from PubMed ==
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[https://www.uniprot.org/uniprot/Q7MZT8_PHOLL Q7MZT8_PHOLL]
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Anthraquinones, a widely distributed class of aromatic natural products, are produced by a type II polyketide synthase system in the Gram-negative bacterium Photorhabdus luminescens. Heterologous expression of the antABCDEFGHI anthraquinone biosynthetic gene cluster in Escherichia coli identified AntI as an unusual lyase, catalysing terminal polyketide shortening prior to formation of the third aromatic ring. Functional in vitro and in vivo analysis of AntI using X-ray crystallography, structure-based mutagenesis, and molecular simulations revealed that AntI converts a defined octaketide to the tricyclic anthraquinone ring via retro-Claisen and Dieckmann reactions. Thus, AntI catalyses a so far unobserved multistep reaction in this PKS system.
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Molecular mechanism of polyketide shortening in anthraquinone biosynthesis of Photorhabdus luminescens.,Zhou Q, Brauer A, Adihou H, Schmalhofer M, Saura P, Grammbitter GLC, Kaila VRI, Groll M, Bode HB Chem Sci. 2019 May 14;10(25):6341-6349. doi: 10.1039/c9sc00749k. eCollection 2019, Jul 7. PMID:31341589<ref>PMID:31341589</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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<div class="pdbe-citations 6hxa" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Adihou, H]]
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[[Category: Photorhabdus luminescens]]
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[[Category: Bode, H]]
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[[Category: Adihou H]]
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[[Category: Braeuer, A]]
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[[Category: Bode H]]
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[[Category: Grammbitter, G]]
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[[Category: Braeuer A]]
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[[Category: Groll, M]]
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[[Category: Grammbitter G]]
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[[Category: Kaila, V R.I]]
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[[Category: Groll M]]
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[[Category: Saura, P]]
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[[Category: Kaila VRI]]
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[[Category: Schmalhofer, M]]
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[[Category: Saura P]]
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[[Category: Zhou, Q]]
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[[Category: Schmalhofer M]]
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[[Category: Alpha]]
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[[Category: Zhou Q]]
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[[Category: Beta-hydrolase fold]]
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[[Category: Cascade reaction]]
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[[Category: Dieckmann condensation]]
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[[Category: Lyase]]
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[[Category: Natural product biosynthesis]]
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[[Category: Retro claisen reaction]]
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[[Category: Type ii polyketide synthase system]]
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Current revision

AntI from P. luminescens catalyses terminal polyketide shortening in the biosynthesis of anthraquinones

PDB ID 6hxa

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