6iws
From Proteopedia
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==Solution structure of the J-domain of Tid1, a Mitochondrial Hsp40/DnaJ Protein== | ==Solution structure of the J-domain of Tid1, a Mitochondrial Hsp40/DnaJ Protein== | ||
| - | <StructureSection load='6iws' size='340' side='right'caption='[[6iws | + | <StructureSection load='6iws' size='340' side='right'caption='[[6iws]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6iws]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IWS OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6iws]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IWS FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iws OCA], [https://pdbe.org/6iws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iws RCSB], [https://www.ebi.ac.uk/pdbsum/6iws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iws ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DNJA3_HUMAN DNJA3_HUMAN] Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. |
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| + | ==See Also== | ||
| + | *[[DnaJ homolog 3D structures|DnaJ homolog 3D structures]] | ||
| + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Jo | + | [[Category: Jo KS]] |
| - | [[Category: Kim | + | [[Category: Kim JH]] |
| - | [[Category: Sim | + | [[Category: Sim DW]] |
| - | [[Category: Won | + | [[Category: Won HS]] |
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Current revision
Solution structure of the J-domain of Tid1, a Mitochondrial Hsp40/DnaJ Protein
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Categories: Homo sapiens | Large Structures | Jo KS | Kim JH | Sim DW | Won HS
