This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
6iws
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
==Solution structure of the J-domain of Tid1, a Mitochondrial Hsp40/DnaJ Protein== | ==Solution structure of the J-domain of Tid1, a Mitochondrial Hsp40/DnaJ Protein== | ||
| - | <StructureSection load='6iws' size='340' side='right'caption='[[6iws | + | <StructureSection load='6iws' size='340' side='right'caption='[[6iws]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[6iws]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IWS OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6iws]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6IWS OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6IWS FirstGlance]. <br> |
| - | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6iws FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6iws OCA], [https://pdbe.org/6iws PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6iws RCSB], [https://www.ebi.ac.uk/pdbsum/6iws PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6iws ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
| - | [ | + | [https://www.uniprot.org/uniprot/DNJA3_HUMAN DNJA3_HUMAN] Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity. Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway. |
| + | |||
| + | ==See Also== | ||
| + | *[[DnaJ homolog 3D structures|DnaJ homolog 3D structures]] | ||
| + | *[[Heat Shock Protein structures|Heat Shock Protein structures]] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
| - | [[Category: Jo | + | [[Category: Jo KS]] |
| - | [[Category: Kim | + | [[Category: Kim JH]] |
| - | [[Category: Sim | + | [[Category: Sim DW]] |
| - | [[Category: Won | + | [[Category: Won HS]] |
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
| - | + | ||
Current revision
Solution structure of the J-domain of Tid1, a Mitochondrial Hsp40/DnaJ Protein
| |||||||||||
Categories: Homo sapiens | Large Structures | Jo KS | Kim JH | Sim DW | Won HS
