6m6k
From Proteopedia
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==NMR solution structure of a DNA minidumbbell containing an abasic bulge between two CCTG repeats== | ==NMR solution structure of a DNA minidumbbell containing an abasic bulge between two CCTG repeats== | ||
- | <StructureSection load='6m6k' size='340' side='right'caption='[[6m6k | + | <StructureSection load='6m6k' size='340' side='right'caption='[[6m6k]]' scene=''> |
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[6m6k]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M6K OCA]. For a <b>guided tour on the structure components</b> use [ | + | <table><tr><td colspan='2'>[[6m6k]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6M6K OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6M6K FirstGlance]. <br> |
- | </td></tr><tr id=' | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> |
- | <tr id=' | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=3DR:1,2-DIDEOXYRIBOFURANOSE-5-PHOSPHATE'>3DR</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr> |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6m6k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6m6k OCA], [https://pdbe.org/6m6k PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6m6k RCSB], [https://www.ebi.ac.uk/pdbsum/6m6k PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6m6k ProSAT]</span></td></tr> |
</table> | </table> | ||
- | <div style="background-color:#fffaf0;"> | ||
- | == Publication Abstract from PubMed == | ||
- | Here we report that incorporation of an abasic site to DNA minidumbbells formed by natural sequences can lead to significant enhancements in their thermodynamic stability. Based on these stable minidumbbells, the first metal ion-controlled molecular switch which can regulate instant and reversible DNA duplex formation and dissociation has been constructed. | ||
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- | Rational design of a reversible Mg(2+)/EDTA-controlled molecular switch based on a DNA minidumbbell.,Wan L, Lam SL, Lee HK, Guo P Chem Commun (Camb). 2020 Sep 1;56(70):10127-10130. doi: 10.1039/d0cc03774e. PMID:32870195<ref>PMID:32870195</ref> | ||
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- | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
- | </div> | ||
- | <div class="pdbe-citations 6m6k" style="background-color:#fffaf0;"></div> | ||
- | == References == | ||
- | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
+ | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Guo | + | [[Category: Guo P]] |
- | [[Category: Lam | + | [[Category: Lam SL]] |
- | [[Category: Wan | + | [[Category: Wan L]] |
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Current revision
NMR solution structure of a DNA minidumbbell containing an abasic bulge between two CCTG repeats
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Categories: Homo sapiens | Large Structures | Guo P | Lam SL | Wan L