6tn9
From Proteopedia
(Difference between revisions)
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<StructureSection load='6tn9' size='340' side='right'caption='[[6tn9]], [[Resolution|resolution]] 2.60Å' scene=''> | <StructureSection load='6tn9' size='340' side='right'caption='[[6tn9]], [[Resolution|resolution]] 2.60Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
- | <table><tr><td colspan='2'>[[6tn9]] is a 1 chain structure with sequence from [ | + | <table><tr><td colspan='2'>[[6tn9]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6TN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6TN9 FirstGlance]. <br> |
- | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NN5:[4-[[6-(3,5-dimethyl-4-oxidanyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]-morpholin-4-yl-methanone'>NN5</scene | + | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6Å</td></tr> |
- | + | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NN5:[4-[[6-(3,5-dimethyl-4-oxidanyl-phenyl)-[1,2,4]triazolo[1,5-a]pyridin-2-yl]amino]phenyl]-morpholin-4-yl-methanone'>NN5</scene></td></tr> | |
- | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6tn9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6tn9 OCA], [https://pdbe.org/6tn9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6tn9 RCSB], [https://www.ebi.ac.uk/pdbsum/6tn9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6tn9 ProSAT]</span></td></tr> | |
- | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | + | |
</table> | </table> | ||
== Function == | == Function == | ||
- | [ | + | [https://www.uniprot.org/uniprot/TTK_HUMAN TTK_HUMAN] Phosphorylates proteins on serine, threonine, and tyrosine. Probably associated with cell proliferation. Essential for chromosome alignment by enhancing AURKB activity (via direct CDCA8 phosphorylation) at the centromere, and for the mitotic checkpoint.<ref>PMID:18243099</ref> |
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==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
- | [[Category: | + | [[Category: Homo sapiens]] |
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[[Category: Large Structures]] | [[Category: Large Structures]] | ||
- | [[Category: Bader | + | [[Category: Bader B]] |
- | [[Category: Boemer | + | [[Category: Boemer U]] |
- | [[Category: Bohlmann | + | [[Category: Bohlmann R]] |
- | [[Category: Brands | + | [[Category: Brands M]] |
- | [[Category: Briem | + | [[Category: Briem H]] |
- | [[Category: Eberspaecher | + | [[Category: Eberspaecher U]] |
- | [[Category: Fernandez-Montalvan | + | [[Category: Fernandez-Montalvan A]] |
- | [[Category: Holton | + | [[Category: Holton SJ]] |
- | [[Category: Klar | + | [[Category: Klar U]] |
- | [[Category: Koppitz | + | [[Category: Koppitz M]] |
- | [[Category: Kosemund | + | [[Category: Kosemund D]] |
- | [[Category: Marquardt | + | [[Category: Marquardt T]] |
- | [[Category: Nguyen | + | [[Category: Nguyen D]] |
- | [[Category: Nussbaum | + | [[Category: Nussbaum F]] |
- | [[Category: Prechtl | + | [[Category: Prechtl S]] |
- | [[Category: Schirok | + | [[Category: Schirok H]] |
- | [[Category: Schulze | + | [[Category: Schulze VK]] |
- | [[Category: Siemeister | + | [[Category: Siemeister G]] |
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Current revision
X-RAY STRUCTURE OF MPS1 IN COMPLEX WITH COMPOUND 16
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Categories: Homo sapiens | Large Structures | Bader B | Boemer U | Bohlmann R | Brands M | Briem H | Eberspaecher U | Fernandez-Montalvan A | Holton SJ | Klar U | Koppitz M | Kosemund D | Marquardt T | Nguyen D | Nussbaum F | Prechtl S | Schirok H | Schulze VK | Siemeister G