6u1o

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Current revision (07:39, 1 May 2024) (edit) (undo)
 
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<StructureSection load='6u1o' size='340' side='right'caption='[[6u1o]]' scene=''>
<StructureSection load='6u1o' size='340' side='right'caption='[[6u1o]]' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U1O FirstGlance]. <br>
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<table><tr><td colspan='2'>[[6u1o]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6U1O OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6U1O FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1o OCA], [https://pdbe.org/6u1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u1o RCSB], [https://www.ebi.ac.uk/pdbsum/6u1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1o ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6u1o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6u1o OCA], [https://pdbe.org/6u1o PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6u1o RCSB], [https://www.ebi.ac.uk/pdbsum/6u1o PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6u1o ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/YIH1_YEAST YIH1_YEAST] Translational regulator that ensures constant high levels of translation under amino acid starvation. Plays a role as a negative regulator of the GCN2 kinase activity; impairs GCN1-mediated GCN2 activation, and hence GCN2-mediated eIF-2-alpha phosphorylation in amino acid-starved cells and subsequent down-regulation of protein synthesis (PubMed:15126500, PubMed:15937339, PubMed:24333428). In normal conditions, it resides in a actin complex and has no activity (PubMed:15126500).<ref>PMID:15126500</ref> <ref>PMID:15937339</ref> <ref>PMID:24333428</ref>
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Saccharomyces cerevisiae S288C]]
[[Category: Edwards PJB]]
[[Category: Edwards PJB]]
[[Category: Goroncy AK]]
[[Category: Goroncy AK]]

Current revision

Structure of two-domain translational regulator Yih1 reveals a possible mechanism of action

PDB ID 6u1o

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