6zxj

==Fully-loaded anthrax lethal toxin in its heptameric pre-pore state, in which the third lethal factor is masked out (PA7LF3-masked)==

<StructureSection load='6zxj' size='340' side='right'caption='[[6zxj]], [[Resolution|resolution]] 3.50&Aring;' scene=''>

<table><tr><td colspan='2'>[[6zxj]] is a 9 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis Bacillus anthracis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZXJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZXJ FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.5&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zxj FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zxj OCA], [https://pdbe.org/6zxj PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zxj RCSB], [https://www.ebi.ac.uk/pdbsum/6zxj PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zxj ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/PAG_BACAN PAG_BACAN] One of the three proteins composing the anthrax toxin, the agent which infects many mammalian species and that may cause death. PA binds to a receptor (ATR) in sensitive eukaryotic cells, thereby facilitating the translocation of the enzymatic toxin components, edema factor and lethal factor, across the target cell membrane. PA associated with LF causes death when injected, PA associated with EF produces edema. PA induces immunity to infection with anthrax.

==See Also==

*[[Anthrax lethal factor 3D structures|Anthrax lethal factor 3D structures]]

[[Category: Bacillus anthracis]]

[[Category: Antoni C]]

[[Category: Raunser S]]