1rv0

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[[Image:1rv0.gif|left|200px]]
[[Image:1rv0.gif|left|200px]]
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{{Structure
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<!--
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|PDB= 1rv0 |SIZE=350|CAPTION= <scene name='initialview01'>1rv0</scene>, resolution 2.5&Aring;
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The line below this paragraph, containing "STRUCTURE_1rv0", creates the "Structure Box" on the page.
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|SITE=
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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|LIGAND= <scene name='pdbligand=DAN:2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC+ACID'>DAN</scene>, <scene name='pdbligand=NDG:2-(ACETYLAMINO)-2-DEOXY-A-D-GLUCOPYRANOSE'>NDG</scene>
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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|ACTIVITY=
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or leave the SCENE parameter empty for the default display.
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|GENE=
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-->
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|DOMAIN=
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{{STRUCTURE_1rv0| PDB=1rv0 | SCENE= }}
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|RELATEDENTRY=[[1ru7|1RU7]], [[1ruy|1RUY]], [[1ruz|1RUZ]], [[1rvt|1RVT]], [[1rvx|1RVX]], [[1rvz|1RVZ]]
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|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1rv0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1rv0 OCA], [http://www.ebi.ac.uk/pdbsum/1rv0 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1rv0 RCSB]</span>
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}}
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'''1930 Swine H1 Hemagglutinin complexed with LSTA'''
'''1930 Swine H1 Hemagglutinin complexed with LSTA'''
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[[Category: Vasisht, N.]]
[[Category: Vasisht, N.]]
[[Category: Xiao, B.]]
[[Category: Xiao, B.]]
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[[Category: hemagglutinin]]
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[[Category: Hemagglutinin]]
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[[Category: influenza a virus]]
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[[Category: Influenza a virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 07:56:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 23:33:19 2008''
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Revision as of 04:56, 3 May 2008

Image:1rv0.gif

Template:STRUCTURE 1rv0

1930 Swine H1 Hemagglutinin complexed with LSTA


Overview

The 1918 influenza pandemic resulted in about 20 million deaths. This enormous impact, coupled with renewed interest in emerging infections, makes characterization of the virus involved a priority. Receptor binding, the initial event in virus infection, is a major determinant of virus transmissibility that, for influenza viruses, is mediated by the hemagglutinin (HA) membrane glycoprotein. We have determined the crystal structures of the HA from the 1918 virus and two closely related HAs in complex with receptor analogs. They explain how the 1918 HA, while retaining receptor binding site amino acids characteristic of an avian precursor HA, is able to bind human receptors and how, as a consequence, the virus was able to spread in the human population.

About this Structure

1RV0 is a Protein complex structure of sequences from Influenza a virus. Full crystallographic information is available from OCA.

Reference

The structure and receptor binding properties of the 1918 influenza hemagglutinin., Gamblin SJ, Haire LF, Russell RJ, Stevens DJ, Xiao B, Ha Y, Vasisht N, Steinhauer DA, Daniels RS, Elliot A, Wiley DC, Skehel JJ, Science. 2004 Mar 19;303(5665):1838-42. Epub 2004 Feb 5. PMID:14764886 Page seeded by OCA on Sat May 3 07:56:38 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

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