6zz6

==Cryo-EM structure of S.cerevisiae cohesin-Scc2-DNA complex==

<StructureSection load='6zz6' size='340' side='right'caption='[[6zz6]], [[Resolution|resolution]] 3.40&Aring;' scene=''>

<table><tr><td colspan='2'>[[6zz6]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6ZZ6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6ZZ6 FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.4&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6zz6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6zz6 OCA], [https://pdbe.org/6zz6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6zz6 RCSB], [https://www.ebi.ac.uk/pdbsum/6zz6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6zz6 ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/SMC1_YEAST SMC1_YEAST] Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.

[[Category: Saccharomyces cerevisiae S288C]]

[[Category: Lee B-G]]

[[Category: Nasmyth KA]]