7ao9

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Current revision (07:45, 1 May 2024) (edit) (undo)
 
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====
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==Structure of the core MTA1/HDAC1/MBD2 NURD deacetylase complex==
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<StructureSection load='7ao9' size='340' side='right'caption='[[7ao9]]' scene=''>
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<StructureSection load='7ao9' size='340' side='right'caption='[[7ao9]], [[Resolution|resolution]] 6.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id= OCA]. For a <b>guided tour on the structure components</b> use [http://proteopedia.org/fgij/fg.htm?mol= FirstGlance]. <br>
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<table><tr><td colspan='2'>[[7ao9]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AO9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AO9 FirstGlance]. <br>
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</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://proteopedia.org/fgij/fg.htm?mol=7ao9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ao9 OCA], [http://pdbe.org/7ao9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=7ao9 RCSB], [http://www.ebi.ac.uk/pdbsum/7ao9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=7ao9 ProSAT]</span></td></tr>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.1&#8491;</td></tr>
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<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=IHP:INOSITOL+HEXAKISPHOSPHATE'>IHP</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ao9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ao9 OCA], [https://pdbe.org/7ao9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ao9 RCSB], [https://www.ebi.ac.uk/pdbsum/7ao9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ao9 ProSAT]</span></td></tr>
</table>
</table>
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== Function ==
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[https://www.uniprot.org/uniprot/MBD2_HUMAN MBD2_HUMAN] Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.<ref>PMID:10471499</ref> <ref>PMID:10947852</ref> <ref>PMID:12665568</ref> <ref>PMID:16415179</ref> <ref>PMID:24307175</ref> <ref>PMID:9774669</ref>
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==See Also==
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*[[Histone deacetylase 3D structures|Histone deacetylase 3D structures]]
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*[[Methyl CpG binding protein 3D structures|Methyl CpG binding protein 3D structures]]
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== References ==
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<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
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[[Category: Z-disk]]
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[[Category: Fairall L]]
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[[Category: Millard CJ]]
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[[Category: Ragan TJ]]
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[[Category: Savva CG]]
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[[Category: Schwabe JWR]]

Current revision

Structure of the core MTA1/HDAC1/MBD2 NURD deacetylase complex

PDB ID 7ao9

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OCA

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