7aqk

==Model of the actin filament Arp2/3 complex branch junction in cells==

<StructureSection load='7aqk' size='340' side='right'caption='[[7aqk]], [[Resolution|resolution]] 9.00&Aring;' scene=''>

<table><tr><td colspan='2'>[[7aqk]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AQK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AQK FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 9&#8491;</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7aqk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7aqk OCA], [https://pdbe.org/7aqk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7aqk RCSB], [https://www.ebi.ac.uk/pdbsum/7aqk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7aqk ProSAT]</span></td></tr>

== Function ==

[https://www.uniprot.org/uniprot/ARP2_MOUSE ARP2_MOUSE] ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In podocytes, required for the formation of lamellipodia downstream of AVIL and PLCE1 regulation. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs).[UniProtKB:P61160]

==See Also==

*[[Actin 3D structures|Actin 3D structures]]

*[[Actin-related protein 3D structures|Actin-related protein 3D structures]]

[[Category: Mus musculus]]

[[Category: Wan W]]